Welcome to LookChem.com Sign In|Join Free


  • or


Post Buying Request

4355-15-1 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

4355-15-1 Usage


α,α''-Dicyano-1,1-cyclohexanediacetamide is a piperidinedione derivative as an analgesic, anticonvulsant and sedative agent.

Check Digit Verification of cas no

The CAS Registry Mumber 4355-15-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,3,5 and 5 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 4355-15:
81 % 10 = 1
So 4355-15-1 is a valid CAS Registry Number.



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017


1.1 GHS Product identifier

Product name 2,4-dioxo-3-azaspiro[5.5]undecane-1,5-dicarbonitrile

1.2 Other means of identification

Product number -
Other names 3,5-Dicyano-4,4-spirocyclohexaneglutarimide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:4355-15-1 SDS

4355-15-1Relevant articles and documents

A 2, 4 - dioxo -3 - aza spiro - [5, 5] undecane - 1, 5 - dinitrile preparation method (by machine translation)


Paragraph 0009; 0035; 0036; 0038; 0040; 0041; 0043; 0045, (2019/03/08)

The present invention provides a 2, 4 - dioxo - 3 - aza-spiro - [5, 5] undecane - 1, 5 - dinitrile preparation method, comprises the following steps: ammonia methanol solution dropping to cyclohexanone and cyanoacetic acid methyl ester in the mixed solution of, thermal insulation reaction, a 2, 4 - dioxo - 3 - aza-spiro - [5, 5] undecane - 1, 5 - [...] solution; then adding water mix, dropping a sulfuric acid solution, thermal insulation reaction, separation, washing, shall be 2, 4 - dioxo - 3 - aza-spiro - [5, 5] undecane - 1, 5 - a dinitrile. The invention provides a 2, 4 - dioxo - 3 - aza-spiro - [5, 5] undecane - 1, 5 - dinitrile preparation method, the process is simple, low in energy consumption, less side reaction, the product yield can reach 98.5% or more, the product of the ammonia nitrogen in the content of less than 0.3%, cyanoacetate of methyl acetate and the unit consumption of 0.85 - 1.1 t/t, is suitable for large-scale industrial production. (by machine translation)

Synthesis of 4-substituted 3,5-dicyano-2,6-piperidinediones using lithium nitride as a convenient source of ammonia

Wu, Liqiang,Yang, Chunguang,Yang, Liming,Yang, Lijuan

experimental part, p. 977 - 982 (2009/09/30)

A simple and efficient one-pot synthesis of 4-substituted-3,5-dicyano-2,6-piperidinediones was achieved in good yields via the three-component reaction of aldehyde or ketone, ethyl cyanoacetate, lithium nitride (Li3N) as a convenient source of ammonia in MeOH.

Antiarthritic and suppressor cell inducing activity of azaspiranes: Structure-function relationships of a novel class of immunomodulatory agents


, p. 2963 - 2970 (2007/10/02)

Spirogermanium (1;8,8-diethyl-N,N-dimethyl-2-aza-8-germaspiro[4.5]decane-2-propanamin e dihydrochloride) is a potent cytotoxic agent in vitro which has demonstrated limited activity in experimental animal tumor models. Subsequently, it has been reported that spirogermanium has antiarthritic and suppressor cell-inducing activity. We have synthesized a series of substituted 8-hetero-2-azaspiro[4.5]decane and 9-hetero-3-azaspiro[5.5]undecane analogues of spirogermanium to identify the heteroatom requirements for in vivo antiarthritic and suppressor cell-inducing activity. This structure-activity relationship study has identified that appropriately substituted silicon and carbon analogues of spirogermanium retain both antiarthritic and immunosuppressive activity, with the 8,8-dipropyl (carbon) analogue being among the most active. Following the identification of N,N-dimethyl-8,8-dipropyl-2-azaspiro[4,5]decane-2-propanamine dihydrochloride (9) as more active analogue than spirogermanium, a series of 8,8-dipropyl analogues with various amine substituents were synthesized. A number of these analogues had activity similar to that of 9. A correlation between activity in the adjuvant arthritic rat and the ability to induce suppressor cells (r = 0.894, p0.001) suggests an association between the two pharmacologic effects. While the precise biochemical mechanism(s) for the pharmacological activity is unclear, these data suggest that compounds within this series, e.g., N,N-dimethyl-8,8-dipropyl-2-azaspiro[4.5]decane-2-propanamine dihydrochloride, may provide effective therapy in diseases of autoimmune origin and/or the prevention of rejection in tissue transplantation.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)


What can I do for you?
Get Best Price

Get Best Price for 4355-15-1