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2-(6-AMINO-9H-PURIN-8-YLSULFANYL)-BUTYRIC ACID, commonly known as 6-thioguanine, is a purine analog compound that serves as a medication for the treatment of various cancers and autoimmune diseases. It functions by inhibiting the growth and spread of cancer cells through the disruption of DNA synthesis and repair, leading to cell death. As a thiopurine drug, 6-thioguanine is metabolized into active thioguanine nucleotides, which are integral to its therapeutic effects. This medication is typically administered orally and has demonstrated efficacy in managing the progression of specific cancer and autoimmune conditions.

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  • 436086-77-0 Structure
  • Basic information

    1. Product Name: 2-(6-AMINO-9H-PURIN-8-YLSULFANYL)-BUTYRIC ACID
    2. Synonyms: TIMTEC-BB SBB007468;2-(6-AMINO-9H-PURIN-8-YLSULFANYL)-BUTYRIC ACID;2-[(6-AMINO-9H-PURIN-8-YL)THIO]BUTANOIC ACID
    3. CAS NO:436086-77-0
    4. Molecular Formula: C9H11N5O2S
    5. Molecular Weight: 253.28
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 436086-77-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 568.8 °C at 760 mmHg
    3. Flash Point: 297.8 °C
    4. Appearance: /
    5. Density: 1.57 g/cm3
    6. Vapor Pressure: 8.95E-14mmHg at 25°C
    7. Refractive Index: N/A
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 2-(6-AMINO-9H-PURIN-8-YLSULFANYL)-BUTYRIC ACID(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2-(6-AMINO-9H-PURIN-8-YLSULFANYL)-BUTYRIC ACID(436086-77-0)
    12. EPA Substance Registry System: 2-(6-AMINO-9H-PURIN-8-YLSULFANYL)-BUTYRIC ACID(436086-77-0)
  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: IRRITANT
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 436086-77-0(Hazardous Substances Data)

436086-77-0 Usage

Uses

Used in Oncology:
6-thioguanine is utilized as an antineoplastic agent for the treatment of leukemia and other types of cancer. It is particularly effective in controlling the progression of certain cancers due to its ability to interfere with the DNA processes of cancer cells, thereby hindering their growth and spread.
Used in Autoimmune Disease Treatment:
In the field of immunology, 6-thioguanine serves as an immunosuppressive drug, used in the management of autoimmune diseases such as Crohn's disease and rheumatoid arthritis. Its mechanism of action involves the suppression of the immune response, reducing inflammation and tissue damage associated with these conditions.
Used in Pharmaceutical Formulations:
6-thioguanine is incorporated into various pharmaceutical formulations designed for oral administration. These formulations are developed to ensure the drug's bioavailability and effectiveness in reaching the target sites within the body, thus maximizing its therapeutic potential.

Check Digit Verification of cas no

The CAS Registry Mumber 436086-77-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,3,6,0,8 and 6 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 436086-77:
(8*4)+(7*3)+(6*6)+(5*0)+(4*8)+(3*6)+(2*7)+(1*7)=160
160 % 10 = 0
So 436086-77-0 is a valid CAS Registry Number.
InChI:InChI=1/C9H11N5O2S/c1-2-4(8(15)16)17-9-13-5-6(10)11-3-12-7(5)14-9/h3-4H,2H2,1H3,(H,15,16)(H3,10,11,12,13,14)/p-1/t4-/m1/s1

436086-77-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-[(6-amino-7H-purin-8-yl)sulfanyl]butanoic acid

1.2 Other means of identification

Product number -
Other names 2-[(6-amino-9H-purin-8-yl)sulfanyl]butanoic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:436086-77-0 SDS

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