436145-52-7

Basic information

• Product Name: (E)-(4S,5R)-5-Acetylamino-4-benzyloxy-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methoxy-pent-2-enoic acid methyl ester
• Synonyms: (E)-(4S,5R)-5-Acetylamino-4-benzyloxy-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methoxy-pent-2-enoic acid methyl ester
• CAS NO: 436145-52-7
• Molecular Weight: 407.464
• Mol File: 436145-52-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-(4S,5R)-5-Acetylamino-4-benzyloxy-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methoxy-pent-2-enoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-(4S,5R)-5-Acetylamino-4-benzyloxy-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methoxy-pent-2-enoic acid methyl ester(436145-52-7)
• EPA Substance Registry System: (E)-(4S,5R)-5-Acetylamino-4-benzyloxy-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methoxy-pent-2-enoic acid methyl ester(436145-52-7)

Safety Data

• Hazardous Substances Data: 436145-52-7(Hazardous Substances Data)

Upstream product

• 16141-78-9 methyl 2-dimethoxyphosphoryl-2-methoxyacetate 
• 436145-50-5 N-[(1S,2R)-2-Benzyloxy-1-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-oxo-propyl]-acetamide 
• 436145-48-1 N-[1-(1-benzyloxy-2-hydroxy-ethyl)-2-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-propyl]-acetamide 
• 436145-49-2 N-[(1R,2R)-2-Benzyloxy-1-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-hydroxy-propyl]-acetamide 
• 1053645-62-7 N-[(1S,2R)-2-Benzyloxy-1-((R)-1,2-dihydroxy-ethyl)-3-hydroxy-propyl]-acetamide 

Downstream Products

• 436145-54-9 (E)-(4S,5S,6R)-5-Acetylamino-4-benzyloxy-6,7-dihydroxy-2-methoxy-hept-2-enoic acid methyl ester 

Relevant articles and documents

A novel approach to the synthesis of amino-sugars. Routes to selectively protected 3-amino-3-deoxy-aldopentoses based on pyridinium salt photochemistry

A new approach for the synthesis of selectively blocked 3-amino-3-deoxyaldopentoses is presented. The strategy is based on employment of a pyridinium salt photocyclization-aziridine ring-opening sequence to prepare stereochemically defined, enantiomerically enriched aminocyclopentendiol derivatives. Ring-opening reactions transform these substances into terminally differentiated aminopolyols, which serve as precursors to the target aminoaldopentoses. The utility of this strategy is demonstrated by its application to the syntheses of protected derivatives of D- and L-3-amino-3-deoxyxylose, L-3-amino-3-deoxyarabinose, and a late-stage intermediate in a potential route to N-acetylneuraminic acid.