436155-36-1

Usage

Uses

Used in Pharmaceutical Synthesis:
2-(3-Methoxyphenoxy)acetohydrazide is used as a key intermediate in the synthesis of pharmaceuticals for its reactivity and versatile chemical properties. It contributes to the development of new drugs by facilitating the creation of diverse molecular structures.
Used in Organic Compounds Synthesis:
In the field of organic chemistry, 2-(3-Methoxyphenoxy)acetohydrazide is used as a building block for the synthesis of various organic compounds, enabling the production of a wide range of chemical entities with potential applications.
Used in Medicinal Chemistry Research:
2-(3-Methoxyphenoxy)acetohydrazide is utilized as a potential precursor in medicinal chemistry research for the preparation of bioactive molecules. Its unique structure allows for the exploration of new chemical spaces and the discovery of novel therapeutic agents.
Used in Drug Discovery and Development:
Due to its potential biological and pharmacological properties, 2-(3-Methoxyphenoxy)acetohydrazide is a target for further investigation in drug discovery and development. Its exploration may lead to the identification of new drug candidates with improved efficacy and safety profiles.

InChI:InChI=1/C9H12N2O3/c1-13-7-3-2-4-8(5-7)14-6-9(12)11-10/h2-5H,6,10H2,1H3,(H,11,12)

Upstream product

• 81720-20-9 methyl (3-methoxyphenoxy)acetate 
• 150-19-6 O-methylresorcine 
• 2088-24-6 3-methoxyphenoxyacetic acid 
• 82815-86-9 (3-methoxy-phenoxy)-acetic acid ethyl ester 

Downstream Products

• 436155-51-0 phenyl 2-[2-(3-methoxyphenoxy)acetyl]hydrazinecarboxylate 

Relevant academic research and scientific papers

Expedient discovery for novel antifungal leads: 1,3,4-Oxadiazole derivatives bearing a quinazolin-4(3H)-one fragment

Developing novel fungicide candidates are intensively promoted by the rapid emergences of resistant fungi that outbreak on agricultural production. Aiming to discovery novel antifungal leads, a series of 1,3,4-oxadiazole derivatives bearing a quinazolin-4(3H)-one fragment were constructed for evaluating their inhibition effects against phytopathogenic fungi in vitro and in vivo. Systematically structural optimizations generated the bioactive molecule I32 that was identified as a promising inhibitor against Rhizoctonia solani with the in vivo preventative effect of 58.63% at 200 μg/mL. The observations that were captured by scanning electron microscopy and transmission electron microscopy demonstrated that the bioactive molecule I32 could induce the sprawling growth of hyphae, the local shrinkage and rupture on hyphal surfaces, the extreme swelling of vacuoles, the striking distortions on cell walls, and the reduction of mitochondria numbers. The above results provided an indispensable complement for the discovery of antifungal lead bearing a quinazolin-4(3H)-one and 1,3,4-oxadiazole fragment.

Design and Synthesis of New 1,3,4-Oxadiazole - Benzothiazole and Hydrazone Derivatives as Promising Chemotherapeutic Agents

Looking for new cytotoxic and antimicrobial agents with improved antitumor activity, a series of hydrazide and oxadiazole derivatives were designed and synthesized using 3-methoxyphenol as starting substance. Novel N'-(arylidene)-2-(3-methoxyphenoxy)aceto

Intramolecular addition of acyldiazenecarboxylates onto double bonds in the synthesis of heterocycles

Appropriate aryl-substituted unsymmetrical azodicarbonyl compounds, generated from bishydrazides by oxidation, undergo intramolecular cyclisations to furnish a variety of useful heterocycles such as N-substituted oxindoles, carbostyrils, benzazepinones, benzazocinones, benzimidazolones, benzoxazinones and pyrazolones in varying degrees of efficiency. Methods are described to remove the N-acyl groups from the heteroaromatic compounds. Under mildly acidic conditions where equal opportunities are available for an ipso or a normal cyclisation it is the former process that occurs preferentially. Evidence is presented in favour of a C-to-C migration in the ipso product for the formation of a methoxy-substituted carbostyril derivative. One of the spiro substances is shown to participate in dienone-phenol rearrangement to provide the corresponding quinolone-phenol in high yield.