4367-75-3Relevant academic research and scientific papers
Exploring structural properties of potent human carbonic anhydrase inhibitors bearing a 4-(cycloalkylamino-1-carbonyl)benzenesulfonamide moiety
Buemi, Maria Rosa,Di Fiore, Anna,De Luca, Laura,Angeli, Andrea,Mancuso, Francesca,Ferro, Stefania,Monti, Simona Maria,Buonanno, Martina,Russo, Emilio,De Sarro, Giovanbattista,De Simone, Giuseppina,Supuran, Claudiu T.,Gitto, Rosaria
, p. 443 - 452 (2019)
Guided by the crystal structure of 4-(3,4-dihydroquinolin-1(2H)-ylcarbonyl)benzenesulfonamide 3 in complex with hCA II (PDB code 4Z0Q), a novel series of cycloalkylamino-1-carbonylbenzenesulfonamides was designed and synthesized. Thus, we replaced the qui
Seeking new approach for therapeutic treatment of cholera disease via inhibition of bacterial carbonic anhydrases: experimental and theoretical studies for sixteen benzenesulfonamide derivatives
Gitto, Rosaria,De Luca, Laura,Mancuso, Francesca,Del Prete, Sonia,Vullo, Daniela,Supuran, Claudiu T.,Capasso, Clemente
, p. 1186 - 1192 (2019/07/15)
A series of sixteen benzenesulfonamide derivatives has been synthesised and tested as inhibitors of Vibrio cholerae carbonic anhydrase (CA) enzymes, belonging to α-CA, β-CA, and γ-CA classes (VchCAα, VchCAβ, and VchCAγ). The determined Ki value
