436844-94-9

Upstream product

• 436844-92-7 4-(2-fluoro-3-pyridinyl)-3-butyn-1-ol 
• 436845-04-4 2-fluoro-3-(4-hydroxybutyl)pyridine 
• 436844-90-5 3-(4-hydroxybutyl)-1-methyl-2(1H)-pyridinone 
• 436845-03-3 methyl 4-(1,2-dihydro-1-methyl-2-oxo-3-pyridinyl)butanoate 
• 436845-05-5 4-(2-fluoro-3-pyridinyl)butyl acetate 
• 436844-93-8 4-(1,2-dihydro-1-methyl-2-oxo-3-pyridinyl)butyl acetate 
• 56826-62-1 1-methyl-5,6,7,8-tetrahydroquinolinium iodide 
• 100095-25-8 4-(1,2-dihydro-1-methyl-2-oxo-3-pyridinyl)butanoic acid 
• 436844-91-6 4-(1,2-dihydro-1-methyl-2-oxo-3-pyridinyl)butanal 
• 117068-71-0 2-(benzyloxy)-6-bromopyridine 

Relevant academic research and scientific papers

Photocycloaddition of four-carbon-tethered pyridones. Intramolecular hydrogen bonding and facilitated amide hydrolysis by a proximal secondary alcohol

Four-carbon-tethered pyridones undergo photocycloaddition to give exclusively trans-[4 + 4] products. The presence of a tether alcohol engenders a solvent-dependent diastereoselectivity for the cycloaddition by intramolecular hydrogen bonding to the adjacent pyridone. Following cycloaddition, the alcohol can deliver a carbonyl group to the proximal, hindered amide nitrogen, leading to a very facile amide hydrolysis.