436864-57-2

Basic information

• Product Name: L-Phenylalanine, 4-[[(1,1-dimethylethoxy)oxoacetyl][2-[(diphenylmethoxy)carbonyl]phenyl] amino]-N-[(2-propenyloxy)carbonyl]-
• CAS NO: 436864-57-2
• Molecular Formula: C39H38N2O9
• Molecular Weight: 678.739
• Mol File: 436864-57-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: L-Phenylalanine, 4-[[(1,1-dimethylethoxy)oxoacetyl][2-[(diphenylmethoxy)carbonyl]phenyl] amino]-N-[(2-propenyloxy)carbonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Phenylalanine, 4-[[(1,1-dimethylethoxy)oxoacetyl][2-[(diphenylmethoxy)carbonyl]phenyl] amino]-N-[(2-propenyloxy)carbonyl]-(436864-57-2)
• EPA Substance Registry System: L-Phenylalanine, 4-[[(1,1-dimethylethoxy)oxoacetyl][2-[(diphenylmethoxy)carbonyl]phenyl] amino]-N-[(2-propenyloxy)carbonyl]-(436864-57-2)

Safety Data

• Hazardous Substances Data: 436864-57-2(Hazardous Substances Data)

Upstream product

• 436864-55-0 2-{4-[2-(S)-tert-butoxycarbonylamino-2-(2-trimethylsilanylethoxycarbonyl)ethyl]phenylamino}-benzoic acid 
• 174833-40-0 N-α-tert-butyloxycarbonyl-β-(p-aminophenyl)-L-alanine 2-(trimethylsilyl)ethyl ester 
• 1488-42-2 Diphenyliodonium-2-carboxylate 
• 582308-06-3 2-({4-[2-(S)-allyloxycarbonylamino-2-(2-trimethylsilanylethoxycarbonyl)-ethyl]-phenyl}-tert-butoxyoxalylamino)-benzoic acid benzhydryl ester 

Downstream Products

• 436864-58-3 methyl 2-{4-[(N-[(allyloxy)carbonyl]-4-{{2-[(benzhydryloxy)carbonyl]phenyl}[tert-butoxy(oxo)acetyl]amino}-L-phenylalanyl)amino]butoxy}-6-hydroxybenzoate 

Relevant articles and documents

Selective protein tyrosine phosphatase 1B inhibitors: Targeting the second phosphotyrosine binding site with non-carboxylic acid-containing ligands

Protein tyrosine phosphatase (PTPase) 1B (PTP1B) has been implicated as a key negative regulator of both insulin and leptin signaling cascades. We identified several salicylic acid-based ligands for the second phosphotyrosine binding site of PTP1B using a NMR-based screening. Structure-based linking with a catalytic site-directed oxalylarylaminobenzoic acid-based pharmacophore led to the identification of a novel series of potent PTP1B inhibitors exhibiting 6-fold selectivity over the highly homologous T-cell PTPase (TCPTP) and high selectivity over other phosphatases.