4369-80-6Relevant academic research and scientific papers
Synthesis and biological properties of novel pyridinioalkanoyl thiolesters (PATE) as anti-HIV-1 agents that target the viral nucleocapsid protein zinc fingers
Turpin, Jim A.,Song, Yongsheng,Inman, John K.,Huang, Mingjun,Wallqvist, Anders,Maynard, Andrew,Covell, David G.,Rice, William G.,Ettore, Appella
, p. 67 - 86 (2007/10/03)
Nucleocapsid p7 protein (NCp7) zinc finger domains of the human immunodeficiency virus type 1 (HIV-1) are being developed as antiviral targets due to their key roles in vital replication and their mutationally nonpermissive nature. On the basis of our exp
Isothiazolones
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, (2008/06/13)
Isothiazolones having the general structure STR1 where A is a monocyclic or bicyclic ring which may contain up to 3 heteroatoms selected from O, S, and N; R1 and R2 are substituent groups such as alkyl, alkoxy, hydroxy, nitro, cyano, amino, and carboxy; and R5 is alkyl, cycloalkyl, phenyl, and Het. The isothiazolones are useful as anti-retroviral agents, anti-inflammatory agents, and anti-atherosclerotic agents.
Isothiazolones lower plasma levels of lipoprotein(a)
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, (2008/06/13)
Plasma levels of Lp(a) are lowered by administering an isothiazolone having the general structure STR1 where A is a monocyclic or bicyclic ring which may contain up to 3 heteroatoms selected from O, S, and N; R1 and R2 are substituen
