4370-22-3

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloromethyl-3-methyl-pyridine hydrochloride is used as a key intermediate in the synthesis of various pharmaceuticals for [application reason]. It contributes to the development of antihistamines, antipsychotic drugs, and anti-infective medications, playing a crucial role in addressing various health conditions.
Used in Agrochemical Industry:
In the agrochemical industry, 2-chloromethyl-3-methyl-pyridine hydrochloride is used as a building block for the production of pesticides. Its reactivity and versatility enable the creation of effective pest control agents, contributing to agricultural productivity and crop protection.
Used in Flavors and Fragrances Industry:
2-Chloromethyl-3-methyl-pyridine hydrochloride is also utilized in the manufacturing of flavors and fragrances. Its unique chemical properties allow for the development of novel scents and taste profiles, enhancing the sensory experience in various consumer products.

Upstream product

• 70580-08-4 C₇H₉NO*ClH 
• 52814-41-2 2-(acetoxymethyl)-3-methylpyridine 
• 22710-07-2 2,3-dimethylpyridine 1-oxide 
• 63071-09-0 2-hydroxymethyl-3-methyl pyridine 
• 583-61-9 2,3-Lutidine 

Downstream Products

• 202192-54-9 tris(2-(6-methylpyridine)methyl)amine 

Relevant academic research and scientific papers

5-lipoxygenase-activating protein (FLAP) inhibitors. Part 4: Development of 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin- 2-ylmethoxy)-1 H -indol-2-yl]-2,2-dimethylpropionic acid (AM803), a potent, oral, once daily FLAP inhibitor

The potent 5-lipoxygenase-activating protein (FLAP) inhibitor 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2- ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid 11cc is described (AM803, now GSK2190915). Building upon AM103 (1) (Hutchinson et al. J. Med Chem.2009, 52, 5803-5815; Stock et al. Bioorg. Med. Chem. Lett. 2010, 20, 213-217; Stock et al. Bioorg. Med. Chem. Lett.2010, 20, 4598-4601), SAR studies centering around the pyridine moiety led to the discovery of compounds that exhibit significantly increased potency in a human whole blood assay measuring LTB4 inhibition with longer drug preincubation times (15 min vs 5 h). Further studies identified 11cc with a potency of 2.9 nM in FLAP binding, an IC50 of 76 nM for inhibition of LTB4 in human blood (5 h incubation) and excellent preclinical toxicology and pharmacokinetics in rat and dog. 11cc also demonstrated an extended pharmacodynamic effect in a rodent bronchoalveolar lavage (BAL) model. This compound has successfully completed phase 1 clinical studies in healthy volunteers and is currently undergoing phase 2 trials in asthmatic patients.

NEUROLOGICALLY-ACTIVE COMPOUNDS

Neurologically-active heterocyclic compounds comprising two fused 6-membered rings with nitrogen atoms at positions 1 and 3, a carboxy group at position 4,and a hydroxy group at position 8, with one ring being aromatic. Processes for the preparation of these compounds and their use as pharmaceutical or veterinary agents, in particular for the treatment of neurological conditions, and more specifically neurodegenerative conditions such as Alzheimer's disease.

Side Chain Chlorinations of N-Heterocyclic Compounds by Trichloroisocyanuric Acid (TCC)

N-Heterocyclic compounds such as 2-methylpyridines, 2-methylquinoline, and 2-methylquinoxaline react with trichloroisocyanuric acid (TCC) without the addition of an initiator to provide the corresponding chloromethyl derivatives in good yields.

[1,3]-Dioxolo[4,5-f]benzimidazoles and [1,4]-dioxino[2,3-f]benzimidazoles

Tricyclic ethers of the general formula I STR1 wherein R represents a bond and R1 represents a 1-2C-alkylene radical which is completely or partly substituted by fluorine, or a chlorotrifluoroethylene radical, or R and R1 each represent a difluoromethylene radical, R2 represents hydrogen or a 1-3C-alkyl radical, R3 represents hydrogen or a 1-3C-alkyl or 1-3C-alkoxy radical, R4 represents hydrogen or a 1-3C-alkyl radical and n represents the number 0 or 1, and their salts are new compounds with a marked protective effect on the stomach.