437384-25-3Relevant academic research and scientific papers
Pyrazolopyridines with potent activity against herpesviruses: Effects of C5 substituents on antiviral activity
Gudmundsson, Kristjan S.,Johns, Brian A.,Allen, Scott H.
, p. 1157 - 1161 (2008/09/18)
Synthesis of a series of 5-substituted as well as 5,7-disubstituted 3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-phenylpyrazolo[1,5-a]pyridin-7-amines with potent activity against herpes simplex viruses is described. Synthetic approaches allowing for variation of the substitution pattern are outlined and resulting changes in antiviral activity are highlighted. Several compounds with in vitro antiviral activity similar to or better than acyclovir are described.
