4374-64-5

Upstream product

• 86387-69-1 4,5-dioxo-tetrahydro-furan-3-carboxylic acid ethyl ester 
• 5400-68-0 2-(hydroxyimino)-γ-butyrolactone 
• 13679-70-4 5-methylthiophene-2-carboxaldehyde 
• 33693-66-2 α-Azido-γ-butyrolacton 
• 4701-17-1 5-bromo-2-thiophencarboxaldehyde 
• 54212-01-0 (E)-3-(methoxymethylene)dihydro-2(3H)-furanone 

Relevant academic research and scientific papers

A direct preparation of N-unsubstituted pyrrole-2,5-dicarboxylates from 2-Azidocarboxylic esters

A new and easy method for synthesis of symmetric pyrrole-2,5-dlcarboxylate derivatives via a simple tltanium(IV)-medlated oxidative dimerlzation of 2-azldocarboxyllc esters is described. The process involves a transformation of tltanium(IV) enolates into

Ozonolysis of enol ethers. Part 10. Ozonization of enol ethers from 1,2- and 1,3-dicarbonyl compounds: Direct quantitative synthesis of phthalonic acid anhydride

The results of ozonolyses of enol ethers from 1.2- and 1.3-dicarbonyl compounds presented here strongly indicate that these reactions do not proceed via the established Criegee ozonolysis mechanism for nucleophilic C=C bonds. The quantitative one-step synthesis of phthalonic acid anhydride via ozonolysis of 2-(methoxymethyliden)-1H-inden-1.3(2H)-dione (28a) is described. Furthermore, a revision of the theory of alkene ozonolysis in the presence of tetracyanoethylene (TCNE) is proposed on the basis of a single-electron-transfer (SET) chemistry.

3-(heteroarylalkyene)- and 3-(arylalkylene)-2,4(3H,5H)-heterocyclic diones as cancer chemotherapy drugs

Heterocyclic diones of the class containing 3-(heteroarylalkylene)- and 3(arylalkylene)-2, 4 (3H, 5H)-furandiones, and 3-(heteroarylalkylene)-pyrrolidene diones and -thiophene diones are disclosed as being effective cancer chemotherapy drugs, some of whic