437553-84-9

Basic information

• Product Name: (R)-N-(1-hydroxymethylbut-3-ynyl)-4-methylbenzenesulfonamide
• Synonyms: (R)-N-(1-hydroxymethylbut-3-ynyl)-4-methylbenzenesulfonamide
• CAS NO: 437553-84-9
• Molecular Weight: 253.322
• Mol File: 437553-84-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-N-(1-hydroxymethylbut-3-ynyl)-4-methylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-N-(1-hydroxymethylbut-3-ynyl)-4-methylbenzenesulfonamide(437553-84-9)
• EPA Substance Registry System: (R)-N-(1-hydroxymethylbut-3-ynyl)-4-methylbenzenesulfonamide(437553-84-9)

Safety Data

• Hazardous Substances Data: 437553-84-9(Hazardous Substances Data)

Upstream product

• 211054-14-7 (R)-2-(toluene-4-sulfonylamino)pent-4-ynoic acid 
• 23235-01-0 (R)-2-aminopent-4-ynoic acid 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 437553-86-1 (R)-N-[1-(tert-butyldimethylsilyloxymethyl)but-3-ynyl]-4-methylbenzenesulfonamide 

Relevant articles and documents

Palladium-Catalyzed Cyclization Reactions of Acetylene-Containing Amino Acids

Enantiomerically pure acetylene-containing α-amino acids were used as versatile starting materials for the synthesis of a variety of heterocycles via Pd-mediated cyclization reactions. Depending on the protecting group strategy, both the carboxylate and the amine function of the amino acids could participate in the cyclizations, thus giving rise to oxygen heterocycles (α-aminolactones) and nitrogen heterocycles (cyclic α-amino acid derivatives), respectively. Beside the straightforward cyclization, cyclization/cross-coupling reactions were also successfully carried out to provide the corresponding substituted cyclic amino acid derivatives.