437606-63-8

Upstream product

• 55262-02-7 3-benzyl-cyclobutanone 
• 924893-87-8 4-hydroxy-N,N-dimethyl-5-phenylpentanamide 
• 108-22-5 Isopropenyl acetate 
• 100-44-7 benzyl chloride 
• 928215-58-1 2-benzyl-2-hydroxy-1-methylpyrrrolidin-5-one 
• 140-29-4 phenylacetonitrile 
• 3183-15-1 4-oxo-5-phenylvaleric acid 
• 21175-42-8 (±)-5-benzyldihydrofuran-2(3H)-one 
• 300-57-2 allylbenzene 
• 1108192-11-5 C₁₅H₂₀O₄ 
• 1108192-06-8 C₁₅H₂₂O₄ 

Downstream Products

• 437606-64-9 (R)-1-phenyl-2,5-pentanediol 
• 757954-64-6 (S)-5-phenyl-pentane-1,4-diol 
• 437606-65-0 (R)-1-phenyl-2,5-pentane-bis-mesylate 

Relevant academic research and scientific papers

Preparation of optically active 4-substituted γ-lactones by lipase-catalyzed optical resolution

Optically active 4-substituted γ-lactones (3 and 4) were synthesized effectively using lipase-catalyzed optical resolution. N-methyl-4-hydroxyalkanamides (rac-1a-i) as substrates were prepared from N-methylsuccinimide. The alkylation of N-methylsuccinimid

Lipase-catalyzed kinetic resolution of 2-phenylethanol derivatives and chiral oxa-Pictet-Spengler reaction as the key steps in the synthesis of enantiomerically pure tricyclic amines

A series of 5,6,7,8,9,10-hexahydro-5,9-epoxybenzocycloocten-6-amines have been synthesized and pharmacologically evaluated in receptor binding studies (σ1, σ2, NMDA, κ, and μ receptors). The first key step of the synthesis was a chir

Organocatalytic asymmetric direct vinylogous aldol reactions of γ-crotonolactone with aromatic aldehydes

The direct aldol reaction of γ-crotonolactone and various aromatic aldehydes is catalyzed by bifunctional aminothiourea and aminosquaramide organocatalysts to provide diastereomerically and enantiomerically enriched 5-substituted 2(5H) furanones (γ-buteno

Asymmetrie direct vinylogous aldol reaction of furanone derivatives catalyzed by an axially chiral guanidine base

Ace of Base: The first highly enantioselectlve direct vinylogous aldol reaction of dihalogenated or α-thio-substituted furanones with aldehydes utilizes an axially chiral guanidine base catalyst. The method provides facile access to enantioenriched γ-subs

Synthesis of γ-valerolactones as the tea catechin metabolites

The synthesis of optically active γ-valerolactones in order to characterize the absolute configuration of the one of the (-)-epicatechin gallate metabolites was described. The determination of stereochemistry at C(4) position of γ-valerolactone suggested

Ligand effects in aluminium-catalyzed asymmetric Baeyer-Villiger reactions

Asymmetric Baeyer-Villiger oxidations of racemic and prochiral cyclobutanones can be performed with chiral aluminium-based Lewis acids resulting in products with good enantioselectivities in high yields. By employing substituted BINOL derivatives as ligan

Chemoenzymatic synthesis of enantiomerically pure tricyclic benzomorphan analogues

The key step in the synthesis of enantiomerically pure benzomorphan analogous tricyclic amines 2 is the kinetic resolution of secondary alcohol 7 using the lipase from Pseudomonas fluorescence. The (S)-configured alcohol (S)-7 and the (R)-configured ester