437709-97-2Relevant academic research and scientific papers
First synthesis of caerulomycin B. A new synthesis of caerulomycin C.
Mongin, Florence,Trecourt, Francois,Gervais, Bruno,Mongin, Olivier,Queguiner, Guy
, p. 3272 - 3276 (2007/10/03)
Caerulomycins produced by Streptomyces caeruleus are bipyridinic molecules endowed with antibiotic properties. The first synthesis of caerulomycin B (1) as well as a new synthesis of caerulomycin C (2) are reported. Starting from 3-hydroxypyridine, the same methodology was used to prepare both compounds 1 and 2. Efficiently controlled reactions such as metalation to allow the synthesis of 2,6-diiodo-3,4-dialkoxypyridines, which are key intermediates, and further halogen-lithium exchange and cross-coupling to reach the targets molecules 1 and 2 have been developed.
