437761-30-3Relevant academic research and scientific papers
Design and synthesis of bicyclic pyrimidinone-based HCV NS3 protease inhibitors
Glunz, Peter W.,Douty, Brent D.,Decicco, Carl P.
, p. 785 - 788 (2007/10/03)
A series of bicyclic pyrimidinone-based HCV NS3 protease inhibitors was synthesized via selective C8 position functionalization. Substituted phenylamides and phenylureas were preferred in the S2 binding pocket.
Inhibitors of hepatitis C virus NS3 protease
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, (2008/06/13)
The present invention relates generally to a novel class of pyrimidinones of Formula (I): that are useful as serine protease inhibitors, and more particularly as Hepatitis C virus NS3 protease inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of using the same.
