437762-12-4

Upstream product

• 709-63-7 1-(4-trifluoromethylphenyl)ethanone 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 439084-89-6 C₆H₆O₃S*C₁₇H₁₈F₃N 
• 672906-91-1 (E)-N-(1-(S)-phenylethyl)ethan-1-(4-(trifluoromethyl)phenyl)-1-imine 

Downstream Products

• 27190-69-8 1-ethyl-4-(trifluoromethyl)benzene 
• 84499-73-0 (S)-N-[α-ethyl-4-(trifluoromethyl)benzyl]amine 
• 578027-35-7 (R)-N-[α-ethyl-4-(trifluoromethyl)benzyl]amine 
• 439084-89-6 C₆H₆O₃S*C₁₇H₁₈F₃N 

Relevant academic research and scientific papers

B(C6F5)3-Catalyzed Asymmetric Reductive Amination of Ketones with Ammonia Borane

The first example of metal-free B(C6F5)3-catalyzed asymmetric reduction amination of ketones with chiral α-methylbenzylamine (α-MBA) using ammonia borane as the reductant is reported. This one-pot method has a broad substrate scope and provides various chiral amines in 81-95% yield with 80-99% de. This protocol was further applied in the total synthesis of cinacalcet.

Iron catalyzed diastereoselective hydrogenation of chiral imines

Cyclopentadienone-based iron complexes were used for the first time to successfully catalyze the diastereoselective hydrogenation of enantiopure imines. Chiral amines, including valuable biologically active products, were obtained often as enantiomericall

Process for producing optically active 1-(fluoro- or trifluoromethyl-substituted phenyl) ethylamine and process for purifying same

An optically active 1-(fluoro- or trifluoromethyl-substituted phenyl)ethylamine is produced with high optical purity and in an industrially simple and efficient manner by asymmetrically reducing an optically active imine, obtained by dehydration and conde

OPTICALLY ACTIVE 1-(FLUORO-,TRIFLUOROMETHYL-OR TRIFLUOROMETHOXY-SUBSTITUTED PHENYL)ALKYLAMINE N-MONOALKYL DERIVATIVES AND PROCESS FOR PRODUCING SAME

An optically active 1-(fluoro-, trifluoromethyl- or trifluoromethoxy-substituted phenyl)alkylamine N-monoalkyl derivative represented by the formula [4] is produced by a process including (a) reacting an optically active secondary amine, represented by th

Highly regioselective hydrogenolysis of bis(α-methylbenzyl)amine derivatives affected by the trifluoromethyl substituent on the aromatic ring

(Matrix presented) The highly regioselective hydrogenolysis of bis(α-methylbenzyl)amine derivatives proceeded with influence not from the electronic effect but from the steric effect of the trifluoromethyl substituent on the aromatic ring to provide a practical asymmetric synthesis of trifluoromethyl-substituted α-phenylethylamines.