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Buthionine sulfoximine (BSO) is a synthetic chemical compound that acts as a selective inhibitor of the enzyme glutathione synthetase, which is crucial for the synthesis of glutathione, a vital antioxidant in cells. By inhibiting this enzyme, BSO depletes cellular glutathione levels, leading to increased oxidative stress. This property makes BSO a valuable tool in research for studying the role of glutathione in various biological processes, including oxidative stress responses, cancer cell metabolism, and the effects of certain drugs. It is important to note that BSO is not used for therapeutic purposes in humans due to its potential toxicity and side effects.

4378-14-7

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4378-14-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 4378-14-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,3,7 and 8 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 4378-14:
(6*4)+(5*3)+(4*7)+(3*8)+(2*1)+(1*4)=97
97 % 10 = 7
So 4378-14-7 is a valid CAS Registry Number.
InChI:InChI=1/C8H17NO2S/c1-3-6(2)9-7(4-5-12)8(10)11/h6-7,9,12H,3-5H2,1-2H3,(H,10,11)

4378-14-7Relevant academic research and scientific papers

Rationally engineered variants of S-adenosylmethionine (SAM) synthase: Reduced product inhibition and synthesis of artificial cofactor homologues

Dippe,Brandt,Rost,Porzel,Schmidt,Wessjohann

supporting information, p. 3637 - 3640 (2015/03/30)

S-Adenosylmethionine (SAM) synthase was engineered for biocatalytic production of SAM and long-chain analogues by rational re-design. Substitution of two conserved isoleucine residues extended the substrate spectrum of the enzyme to artificial S-alkylhomocysteines. The variants proved to be beneficial in preparative synthesis of SAM (and analogues) due to a much reduced product inhibition. This journal is

Palatability of aquaculture feed

-

, (2008/06/13)

A method for enhancing the palatability of aquaculture food, the method comprising treating the food with a compound of Formula I: wherein R1, R2, R3, and n are as defined herein, are disclosed.

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