4378-36-3 Usage
Originator
Phenbutrazate,Shanghai Lansheng
Uses
Fenbutrazate is a derivative of Phenmetrazine (P314500). Fenbutrazate is a psychostimulant used as an anorexigen (appetite suppressant).
Manufacturing Process
1105 g of 2-phenyl-3-methyl-4-(α-hydroxyethyl)-tetrahydro-1,4-oxazine-(4-
(2-hydroxyethyl)-3-methyl-2-phenylmorphotine) are dissolved in 4000 ml of
anhydrous toluene. 910 g of α-phenyl-α-ethyl acetic acid chloride (2-ethyl-2-
phenyl-acetylchloride) are dissolved in 400 ml of anhydrous toluene and the
resulting solution is slowly added to the heated solution of the tetrahydro-1,4-
oxazine compound. The mixture is then heated to boiling for about 5 hours.
About 1000 g of ice are added to the cooled reaction mixture, which is then
rendered alkaline by the addition of 20% sodium carbonate solution to a pH of
9.0. Thereafter the mixture is vigorously stirred by means of a turbine mixer
for one hour and the toluene phase is separated. The toluene solution is
washed with 1000 ml of saturated sodium chloride solution and is dried over
anhydrous sodium sulfate. The toluene is then evaporated and the residue is
subjected to high vacuum distillation. 1650 g of α-phenyl-α-ethylacetic acid
(2-phenyl-3-methyltetrahydro-1,4-oxazine)-N-ethyl ester (fenburazate),
boiling at 235°-240°C/0.05 mm are obtained thereby in a yield of 90.5% of
the theoretical yield.
Therapeutic Function
Anorexic, Central stimulant
Check Digit Verification of cas no
The CAS Registry Mumber 4378-36-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,3,7 and 8 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 4378-36:
(6*4)+(5*3)+(4*7)+(3*8)+(2*3)+(1*6)=103
103 % 10 = 3
So 4378-36-3 is a valid CAS Registry Number.
InChI:InChI=1/C23H29NO3/c1-3-21(19-10-6-4-7-11-19)23(25)27-17-15-24-14-16-26-22(18(24)2)20-12-8-5-9-13-20/h4-13,18,21-22H,3,14-17H2,1-2H3
