437986-94-2Relevant academic research and scientific papers
Delta agonist hydroxy bioisosteres: The discovery of 3-((1-benzylpiperidin-4-yl){4-[(diethylamino)carbonyl]phenyl}amino)benzamide with improved delta agonist activity and in vitro metabolic stability
Griffin, Andrew M.,Brown, William,Walpole, Christopher,Coupal, Martin,Adam, Lynda,Gosselin, Mylene,Salois, Dominic,Morin, Pierre-Emmanuel,Roumi, Marie
scheme or table, p. 5999 - 6003 (2010/05/18)
We have investigated phenol replacements in a series of diaryl amino piperidine delta opioid agonists. From this study we have demonstrated that the hydroxy functional group can be replaced with a primary amide group, giving enhanced activity at the delta
