4380-92-1

Basic information

• Product Name: 2,4,6-MesitylenetriaMine
• Synonyms: 2,4,6-MesitylenetriaMine;(3,5-diamino-2,4,6-trimethyl-phenyl)amine;2,4,6-Trimethyl-1,3,5-benzenetriamine hydrochloride;1,3,5-Triamino-2,4,6-trimethylbenzene;2,4,6-Triaminomesitylene;2,4,6-Trimethylbenzene-1,3,5-triamine hydrochloride
• CAS NO: 4380-92-1
• Molecular Formula: C₉H₁₅N₃
• Molecular Weight: 165.2355
• Product Categories: Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 4380-92-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 365.8±37.0 °C(Predicted)
• Appearance: /
• Density: 1.138±0.06 g/cm3(Predicted)
• Solubility: Methanol
• PKA: 5.19±0.10(Predicted)
• CAS DataBase Reference: 2,4,6-MesitylenetriaMine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,6-MesitylenetriaMine(4380-92-1)
• EPA Substance Registry System: 2,4,6-MesitylenetriaMine(4380-92-1)

Safety Data

• Hazardous Substances Data: 4380-92-1(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

2,4,6-MesitylenetriaMine is an intermediate in the synthesis of trimethylphloroglucinol (T796600), a phloroglucinol derivative used to reduce the pain intensity of irritable bowel syndrome.

Upstream product

• 108-67-8 1,3,5-trimethyl-benzene 
• 602-96-0 2,4,6-trinitromesitylene 

Downstream Products

• 65373-49-1 2,4,6-trimethyl-benzene-1,3,5-triyl triisocyanate 
• 500334-49-6 N,N',N''-(trimethyl-benzene-1,3,5-triyl)-tris-benzenesulfonamide 
• 855231-31-1 N,N',N''-triethyl-N,N',N''-(trimethyl-benzene-1,3,5-triyl)-tris-benzenesulfonamide 

Relevant articles and documents

Synthesis of triisocyanomesitylene β?diketiminato copper(I) complexes and evaluation of isocyanide π-back bonding

A new 2,4,6-triisocyanomesitylene ligand was synthesized and along with 1,4-isocyanobenzene utilized to prepare unique N-aryl-N′-alkylpyridyl β-diketiminato copper(I) complexes. Crystallographic characterization of 2,4,6-triisocyanomesitylene, dinuclear a

Synthetic method for 2,4,6-trimethylbenzene-1,3,5-triamine and N,N,N-triacylated product

The invention provides a synthetic method for 2,4,6-trimethylbenzene-1,3,5-triamine and an N,N,N-triacylated product. The method comprises the following steps: S1, performing a nitration reaction on mesitylene with structural formula IV as a reaction raw material in the presence of a mixed acid of fuming nitric acid and concentrated sulfuric acid, and after the nitration reaction, performing filtration and drying to obtain 1,3,5-trimethyl-2,4,6-trinitryl benzene with structural formula III; S2, performing a hydrogenation reaction on 1,3,5-trimethyl-2,4,6-trinitryl benzene and a reducer hydrazine hydrate to reduce nitryl to amino, and performing purification to obtain 2,4,6-trimethylbenzene-1,3,5-triamine with structure formula II; and S3, performing an acylation reaction on 2,4,6-trimethylbenzene-1,3,5-triamine and an acylation reagent to obtain N,N,N-triacyl-2,4,6-trimethylbenzene-1,3,5-triamine with structural formula I.

Reaction chemistry of tri-substituted mesitylene derivatives and the synthesis of sterically buttressed 1,3,5-triaminocyclohexyl ligands

The sterically buttressed triamine cis,cis-2,4,6-trimethyl-1,3,5-triaminocyclohexane is weakly basic in aqueous solution (pKa: 7.83, 6.73, 5.15; 298 K) because of steric inhibition to solvation. As a result of intramolecular hydrogen-bonding an