4380-92-1

Basic information

• Product Name: 2,4,6-MesitylenetriaMine
• Synonyms: 2,4,6-MesitylenetriaMine;(3,5-diamino-2,4,6-trimethyl-phenyl)amine;2,4,6-Trimethyl-1,3,5-benzenetriamine hydrochloride;1,3,5-Triamino-2,4,6-trimethylbenzene;2,4,6-Triaminomesitylene;2,4,6-Trimethylbenzene-1,3,5-triamine hydrochloride
• CAS NO: 4380-92-1
• Molecular Formula: C₉H₁₅N₃
• Molecular Weight: 165.2355
• Product Categories: Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 4380-92-1.mol

Chemical Properties

• Boiling Point: 365.8±37.0 °C(Predicted)
• Appearance: /
• Density: 1.138±0.06 g/cm3(Predicted)
• Solubility: Methanol
• PKA: 5.19±0.10(Predicted)
• CAS DataBase Reference: 2,4,6-MesitylenetriaMine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,6-MesitylenetriaMine(4380-92-1)
• EPA Substance Registry System: 2,4,6-MesitylenetriaMine(4380-92-1)

Safety Data

• Hazardous Substances Data: 4380-92-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,4,6-MesitylenetriaMine is used as an intermediate in the synthesis of trimethylphloroglucinol (T796600), a phloroglucinol derivative. 2,4,6-MesitylenetriaMine is utilized for its therapeutic effects in reducing the pain intensity associated with irritable bowel syndrome, a common gastrointestinal disorder.
In the synthesis process, 2,4,6-MesitylenetriaMine plays a crucial role in the formation of the final product, trimethylphloroglucinol, which exhibits the desired pharmacological properties. The intermediate's reactivity and structural features enable the development of effective treatments for managing the symptoms of irritable bowel syndrome, improving the quality of life for those affected by this condition.

Upstream product

• 602-96-0 2,4,6-trinitromesitylene 
• 108-67-8 1,3,5-trimethyl-benzene 

Downstream Products

• 65373-49-1 2,4,6-trimethyl-benzene-1,3,5-triyl triisocyanate 
• 173437-79-1 cis-cis-2,4,6-trimethyl-1,3,5-triaminocyclohexane 
• 1538579-86-0 1,3,5-tris(isonicotinamidomethyl)-2,4,6-trimethylbenzene 
• 1377871-01-6 2,4,6-tris(bromomethyl)-N₁,N₁,N₃,N₃,N₅,N₅-hexakis(tert-butoxycarbonyl)-2,4,6-trimethylbenzene-1,3,5-triamine 
• 1377870-95-5 2,4,6-tris(bromomethyl)-N₁,N₃,N₅-tris(tert-butoxycarbonyl)-2,4,6-trimethylbenzene-1,3,5-triamine 
• 1377871-00-5 N₁,N₁,N₃,N₃,N₅,N₅-hexakis(tertbutoxycarbonyl)-2,4,6-trimethylbenzene-1,3,5-triamine 
• 1377870-97-7 N₁,N₃,N₅-tris(tert-butoxycarbonyl)-2,4,6-trimethylbenzene-1,3,5-triamine 
• 855231-31-1 N,N',N''-triethyl-N,N',N''-(trimethyl-benzene-1,3,5-triyl)-tris-benzenesulfonamide 

Relevant articles and documents

Synthesis of triisocyanomesitylene β?diketiminato copper(I) complexes and evaluation of isocyanide π-back bonding

A new 2,4,6-triisocyanomesitylene ligand was synthesized and along with 1,4-isocyanobenzene utilized to prepare unique N-aryl-N′-alkylpyridyl β-diketiminato copper(I) complexes. Crystallographic characterization of 2,4,6-triisocyanomesitylene, dinuclear a

New Mesomorphic Compounds: N,N',N''-Trialkanoyl-2,4,6-trimethyl-1,3,5-benzenetriamines

The homologous series of N,N',N''-trialkanoyl-2,4,6-trimethyl-1,3,5-benzenetriamines has been prepared.The viscous birefringent melts are given by the butyryl to hexadecanoyl derivatives.The X-ray diffraction pattern recorded for the octanoyl derivative a

Synthetic method for 2,4,6-trimethylbenzene-1,3,5-triamine and N,N,N-triacylated product

The invention provides a synthetic method for 2,4,6-trimethylbenzene-1,3,5-triamine and an N,N,N-triacylated product. The method comprises the following steps: S1, performing a nitration reaction on mesitylene with structural formula IV as a reaction raw material in the presence of a mixed acid of fuming nitric acid and concentrated sulfuric acid, and after the nitration reaction, performing filtration and drying to obtain 1,3,5-trimethyl-2,4,6-trinitryl benzene with structural formula III; S2, performing a hydrogenation reaction on 1,3,5-trimethyl-2,4,6-trinitryl benzene and a reducer hydrazine hydrate to reduce nitryl to amino, and performing purification to obtain 2,4,6-trimethylbenzene-1,3,5-triamine with structure formula II; and S3, performing an acylation reaction on 2,4,6-trimethylbenzene-1,3,5-triamine and an acylation reagent to obtain N,N,N-triacyl-2,4,6-trimethylbenzene-1,3,5-triamine with structural formula I.

A new synthetic strategy to prepare throne and calix diastereoisomers of parallel tris-Trger's bases

The calix diastereoisomers of the parallel tris-Trger's base (tris-TB) derivatives were suggested as potential cavitands in 2002, and the first members of this cavitand family were introduced in 2007. The synthetic strategy enabling the preparation of nap

Reaction chemistry of tri-substituted mesitylene derivatives and the synthesis of sterically buttressed 1,3,5-triaminocyclohexyl ligands

The sterically buttressed triamine cis,cis-2,4,6-trimethyl-1,3,5-triaminocyclohexane is weakly basic in aqueous solution (pKa: 7.83, 6.73, 5.15; 298 K) because of steric inhibition to solvation. As a result of intramolecular hydrogen-bonding an

Conformationally Biased Tri- and Di-basic 1,3,5-Triazacyclohexyl Ligands

The biased ligand cis-cis-2,4,6-trimethyl-1,3,5-triaminocyclohexane is weakly basic and may be converted into di- and tri-basic complexing agents bearing hydroxyphenyl, carboxylate or phosphinate groups; an unusual tricyclic bis-aminal intermediate hydrol