438240-39-2

Upstream product

• 42807-86-3 tert-butyl (2S)-4-methyl-2-(methylamino)pentanoate 
• 438240-71-2 (S)-2-[((2S,4R)-2-{(S)-3-(4-Benzyloxy-phenyl)-2-[((S)-2-tert-butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-propionylamino}-4-methyl-octanoyl)-methyl-amino]-propionic acid methyl ester 
• 251555-89-2 (S)-3-(4-Benzyloxy-phenyl)-2-[((S)-2-tert-butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-propionic acid methyl ester 
• 237431-25-3 N-<(2S,4R)-2--4-methylheptanoyl>-N-methyl-L-leucine tert-butyl ester 
• 237431-27-5 N-<(2S,4R)-2--4-methylheptanoyl>-N-methyl-L-alanine methyl ester 
• 237431-18-4 N-Boc-PrLeu 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 237431-26-4 N-<(2S,4R)-2-amino>-4-methylheptanoyl>-N-methyl-L-leucine tert-butyl ester 

Downstream Products

• 438239-98-6 3-[(2R,5S,8S,11S,14S,17S,20S)-14-(4-Benzyloxy-benzyl)-8,11-diisobutyl-7,13,19,20-tetramethyl-5,17-bis-((R)-2-methyl-hexyl)-3,6,9,12,15,18,21-heptaoxo-1-oxa-4,7,10,13,16,19-hexaaza-cyclohenicos-2-yl]-propionitrile 

Relevant academic research and scientific papers

Solution-phase parallel synthesis of a pharmacophore library of HUN-7293 analogues: A general chemical mutagenesis approach to defining structure-function properties of naturally occurring cyclic (depsi)peptides

HUN-7293 (1), a naturally occurring cyclic heptadepsipeptide, is a potent inhibitor of cell adhesion molecule expression (VCAM-1, ICAM-1, E-selectin), the overexpression of which is characteristic of chronic inflammatory diseases. Representative of a gene