438461-29-1

Upstream product

• 27527-05-5 L-cyclohexylalanine 
• 643-79-8 o-phthalic dicarboxaldehyde 
• 307310-72-1 (S)-(+)-α-aminocyclohexanepropionic acid hydrate 

Downstream Products

• 438460-77-6 (S)-3-cyclohexyl-2-(1-oxo-1,3-dihydro-isoindol-2-yl)-N-thiazol-2-yl-propionamide 
• 1407232-75-0 (S)-3-cyclohexyl-N-[1-(2-methoxy-ethyl)-1H-pyrazol-3-yl]-2-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionamide 

Relevant academic research and scientific papers

ISOINDOLINONE DERIVATIVES

The present invention relates to compounds of the formula I, as well as pharmaceutically-acceptable salts thereof, pharmaceutical compositions containing said compounds and methods of using said compounds in the treatment or prophylaxis of diseases and disorders. The compounds and compositions disclosed herein are glucokinase activators useful for the treatment or prophylaxis of metabolic diseases and disorders, for example diabetes mellitus, including type II diabetes mellitus.

Isoindolin-1-one glucokinase activators

Isoindolin-1-one-substituted propionamide glucokinase activators which increase insulin secretion in the treatment of type II diabetes.