438477-05-5Relevant academic research and scientific papers
Stereoselective synthesis of anti-α-(difluoromethyl)-β-amino alcohols by boronic acid based three-component condensation. Stereoselective preparation of (2S,3R)-difluorothreonine
Prakash, G. K. Surya,Mandal, Mihirbaran,Schweizer, Stefan,Petasis, Nicos A.,Olah, George A.
, p. 3718 - 3723 (2002)
Starting from optically active 3,3-difluorolactaldehyde, an alkenyl or aryl boronic acid, and an amine, a one-step three-component methodology was developed for the stereoselective preparation of anti-α-(difluoromethyl)-β-amino alcohols. β-Furyl-substituted anti-α-(difiuoromethyl)-β-amino alcohol was further elaborated to form (2S,3R)-difluorothreonine in high yield and ee.
