4385-74-4

Upstream product

• 24398-88-7 ethyl 3-bromobenzoate 
• 1120-87-2 4-bromopyridin 
• 4334-87-6 [3-(ethoxycarbonyl)phenyl]boronic acid 
• 1692-15-5 4-pyridylboronic acid 
• 110-86-1 pyridine 

Downstream Products

• 579475-42-6 3-[3-(2-cyano-pyridin-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester 
• 579475-46-0 3-(1-oxy-pyridin-4-yl)-benzoic acid ethyl ester 

Relevant academic research and scientific papers

Structure-activity relationship studies for the development of inhibitors of murine adipose triglyceride lipase (ATGL)

High serum fatty acid (FA) levels are causally linked to the development of insulin resistance, which eventually progresses to type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) generalized in the term metabolic syndrome. Adipose triglyceride lipase (ATGL) is the initial enzyme in the hydrolysis of intracellular triacylglycerol (TG) stores, liberating fatty acids that are released from adipocytes into the circulation. Hence, ATGL-specific inhibitors have the potential to lower circulating FA concentrations, and counteract the development of insulin resistance and NAFLD. In this article, we report about structure–activity relationship (SAR) studies of small molecule inhibitors of murine ATGL which led to the development of Atglistatin. Atglistatin is a specific inhibitor of murine ATGL, which has proven useful for the validation of ATGL as a potential drug target.

COMPOUNDS FOR NONSENSE SUPPRESSION, AND METHODS FOR THEIR USE

The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.

Synthesis of functionalized 4-phenyl-pyridines via electrochemically prepared organozinc reagents

The efficient and convenient synthesis of various functionalized 4-phenyl-pyridines 2 is described. The key step of the procedure is the electrochemical formation of aromatic organozinc reagents 1 and their coupling with pyridinium salts. Intermediate 1,4