438533-39-2

Upstream product

• 930-68-7 cyclohexenone 
• 552-89-6 2-nitro-benzaldehyde 

Downstream Products

• 1262135-29-4 2-(hydroxy(2-nitrophenyl)methyl)cyclohex-2-enone oxime 
• 1262135-01-2 3-(2-nitrophenyl)-3,5,6,7-tetrahydrobenzo[c]isoxazole-1-oxide 
• 1401088-01-4 (E)-2-(2-nitrobenzylidene)-3-(2-phenyl-1H-indol-3-yl)-cyclohexanone 
• 1401088-05-8 (Z)-2-(2-nitrobenzylidene)-3-(2-phenyl-1H-indol-3-yl)-cyclohexanone 

Relevant academic research and scientific papers

Lewis base effects in the Baylis-Hillman reaction of arenecarbaldehydes and N-arylidene-4-methylbenzenesulfonamides with α,β-unsaturated cyclic ketones

In investigations into the Baylis-Hillman reaction between arenecarbaldehydes and 2-cyclohexen-1-one or 2-cyclopenten-1-one, we found that the reaction is very complicated, because the Lewis bases, solvents, the substrates, and the ring-size of the α,β-un

Bifunctional polymeric organocatalysts and their application in the cooperative catalysis of Morita-Baylis-Hillman reactions

A series of soluble, noncross-linked polystyrene-supported tri-phenylphosphane and 4-dimethylaminopyridine reagents were prepared. Some of these polymeric reagents contained either alkyl alcohol or phenol groups on the polymer backbone. The use of these materials as organocatalysts in a range of Morita-Baylis-Hillman reactions indicated that hydroxyl groups could participate in the reactions and accelerate product formation. In the cases examined, phenol groups were more effective than alkyl alcohol groups for catalyzing the reactions. This article is one of the first reports of the synthesis and use of non-natural, bifunctional polymeric reagents for use in organic synthesis in which both functional groups can cooperatively participate in the catalysis of reactions.

N-Methylmorpholine and urotropine as useful base catalysts in Baylis-Hillman reaction

N-Methylmorpholine and urotropine, inexpensive mild bases, have effectively been utilized as catalysts in Baylis-Hillman reaction to result in good to excellent yields (57-99%) of the products.

Remarkable Rate Acceleration of Imidazole-Promoted Baylis-Hillman Reaction Involving Cyclic Enones in Basic Water Solution

The Baylis-Hillman reaction of cyclic enones was greatly accelerated in basic water solution with imidazoles as catalysts, which resulted in short reaction time, high yields, and expanding substrate scopes. Bicarbonate solution was shown to be the optimal

Simple, facile, and one-pot conversion of the Baylis-Hillman adducts into functionalized 1,2,3,4-tetrahydroacridines and cyclopenta[b]quinolines

A simple, facile, and one-pot synthesis of functionalized 1,2,3,4-tetrahydroacridines and cyclopenta[b]-quinolines from the Baylis-Hillman alcohols, i.e., 2-[hydroxy-(2-nitroaryl)methyl]cycloalk-2-enones, is described.