438566-60-0

Upstream product

• 438566-41-7 (3R,4S)-3-benzyloxy-1-[(2S)-2-(1-ethyl-1-methoxypropyl)pyrrolidin-1-yl]-4-pentylazetidin-2-one 
• 19810-31-2 Benzyloxyacetyl chloride 
• 66-25-1 hexanal 
• 118535-69-6 [(S)-2-(1-Ethyl-1-methoxy-propyl)-pyrrolidin-1-yl]-hex-(Z)-ylidene-amine 

Relevant academic research and scientific papers

Studies on stereoselective [2+2] cycloadditions between N,N-dialkylhydrazones and ketenes

Staudinger-like cycloadditions between chiral, non-racemic N,N-dialkylhydrazones 1 and functionalized ketenes constitute an efficient methodology for the stereoselective construction of the β-lactam ring. The potential for fine tuning of the dialkylamino

N,N-dialkylhydrazones as the imine component in the Staudinger-like [2+2] cycloaddition to benzyloxyketene

To overcome the limitations of using unstable imines in Staudinger cycloadditions to ketenes, aldehyde N,N-dialkylhydrazones 1 were used as stable imines. This strategy and a fine tuning of the auxiliary result in a straightforward synthesis of cycloadducts 2, deprotected β-lactams 3, and isoserines 4 (see scheme: a) Et3N, toluene, Δ; b) 1. magnesium monoperoxyphthalate, 2. H2, Pd/C; c) H+).