438566-71-3Relevant academic research and scientific papers
Preparation of poly and diversely substituted N-alkylated and free-NH isoindolin-1-ones
Couture, Axel,Deniau, Eric,Lamblin, Marc,Lorion, Magali,Grandclaudon, Pierre
, p. 1434 - 1437 (2008/02/13)
A variety of diversely substituted N-alkylated and free-NH isoindolin-1-ones have been efficiently prepared by treatment of suitably substituted di- and monoacylated halobenzylamines, respectively, with a lithiated base. Georg Thieme Verlag Stuttgart.
A short total synthesis of the alkaloids piperolactam C, goniopedaline, and stigmalactam
Rys, Veronique,Couture, Axel,Deniau, Eric,Grandclaudon, Pierre
, p. 1231 - 1237 (2007/10/03)
The total synthesis of the polyalkoxylated alkaloids piperolactam C, goniopedaline and stigmalactam by combinatorial metalation/cyclization strategies has been achieved. The synthetic route involved the preliminary construction of the polyalkoxylated isoindolinone template by Parham's technique. Benzylic lactam deprotonation allowed connection of a hydroxybenzyl appendage, and the synthesis of the target natural products was completed by subsequent E1cB elimination, radical cyclization and final deprotection. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.
