438624-01-2Relevant academic research and scientific papers
Carbocyclic[g]indole inhibitors of human nonpancreatic s-PLA2
Sawyer, J. Scott,Beight, Douglas W.,Smith, Edward C. R.,Snyder, David W.,Chastain, Marcia K.,Tielking, Richard L.,Hartley, Lawrence W.,Carlson, Donald G.
, p. 893 - 896 (2007/10/03)
A vinyl azide cyclization method was used to synthesize three different carbocyclic[g]indole scaffolds as inhibitors of human nonpancreatic secretory phospholipase A2. Each scaffold demonstrated potent enzyme activity in a chromogenic assay sys
Novel spla2 inhibitors
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, (2008/06/13)
A novel class of cycloalkyl fused indole compounds is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
