439088-74-1

Usage

Uses

Used in Pharmaceutical Industry:
Glycine, (2R)-2-phenylglycyl-, 1,1-dimethylethyl ester is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to be incorporated into the structure of complex organic compounds, enhancing the development of drugs that target specific proteins and enzymes.
Used in Peptide Synthesis:
In the field of peptide synthesis, Glycine, (2R)-2-phenylglycyl-, 1,1-dimethylethyl ester is used as a building block to create peptides with specific biological activities, contributing to the advancement of therapeutic agents and diagnostic tools.
Used in Organic Chemistry:
Glycine, (2R)-2-phenylglycyl-, 1,1-dimethylethyl ester is utilized as a reagent in organic chemistry for the synthesis of natural products and other organic materials, showcasing its versatility in creating a wide range of chemical compounds.

Upstream product

• 17609-52-8 Z-D-phenylglycine 
• 439088-73-0 (R)-N-benzyloxycarbonyl-α-[N-(t-butoxycarbonylmethyl)carbamoyl]benzylamine 

Downstream Products

• 439088-90-1 1,1-dioxo-3,3-dibutyl-5-(4-chlorophenyl)-7-methylthio-8-[N-{(R)-α-[N'-(t-butoxycarbonylmethyl)carbamoyl]benzyl}carbamoylmethoxy]-2,3,4,5-tetrahydro-1,5-benzothiazepine 
• 439088-54-7 tert-butyl-N-{(2R)-2-[({[3,3-dibutyl-7-(methylthio)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-8-yl]oxy}acetyl)amino]-2-phenylethanoyl}glycinate 
• 501692-12-2 1,1-dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(N-{(R)-α-[N-(carboxymethyl)carbamoyl]benzyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,2,5-benzothiadiazepine 
• 439087-95-3 1,1-Dioxo-3,3-dipropyl-5-phenyl-7-methylthio-8-[N-{(R)-α-[N'-(carboxymethyl)carbamoyl]-4-hydroxybenzyl}carbamoylmethoxy]-2,3,4,5-tetrahydro-1,5-benzothiazepine 
• 753010-66-1 3,5-trans-1,1-dioxo-3-ethyl-3-butyl-5-phenyl-7-methythio-8-(N-{(R)-α-[N-(t-butoxycarbonylmethyl)carbamoyl]benzyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,4-benzothiazepine 

Relevant academic research and scientific papers

PROCESS FOR THE PREPARATION OF 1,5-BENZOTHIAZEPINE COMPOUNDS

The present invention relates to a process for the preparation of certain 1,5-benzothiazepine compounds, and in particular to a process for the preparation of elobixibat. The process can be carried out under mild and safe conditions and may be used to pre

BENZOTHIAZEPINE AND BENZOTHIADIAZEPINE DERIVATIVES WITH ILEAL BILE ACID TRANSPORT (IBAT) INHIBITORY ACTIVITY FOR THE TREATMENT HYPERLIPIDAEMIA

The present invention relates to compounds of formula (I) wherein Rv, R1, R2, Rx, Ry, M, Rz, v, R3, R4, R5 and R6 are as defined within; pharmace

DIPHENYLAZETIDINONE DERIVATIVES FOR TREATING DISORDERS OF THE LIPID METABOLISM

Compounds of formula (I): (wherein variable groups are as defined within) pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as cholesterol absorption inhibitors for the treatment of hyperlipidaemia are

Chemical compounds

The present invention relates to compounds of the formula (I): (wherein variable groups are as defined within) pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia. Processes for their manufacture and pharmaceutical compositions containing them are also described. 1