439089-66-4Relevant academic research and scientific papers
A stereoselective synthesis of BMS-262084, an azetidinone-based tryptase inhibitor
Qian, Xinhua,Zheng, Bin,Burke, Brian,Saindane, Manohar T.,Kronenthal, David R.
, p. 3595 - 3600 (2002)
A highly stereoselective synthesis of the novel tryptase inhibitor BMS-262084 was developed. Key to this synthesis was the discovery and development of a highly diastereoselective demethoxycarbonylation of diester 12 to form the trans-azetidinone 13. BMS-262084 was prepared in 10 steps from D-ornithine in 30% overall yield.
