439094-80-1Relevant academic research and scientific papers
Nickel-Catalyzed Coupling of Azoles with Aromatic Nitriles
Hanson, McKenna G.,Olson, Noelle M.,Yi, Zubaoyi,Wilson, Grace,Kalyani, Dipannita
supporting information, p. 4271 - 4274 (2017/08/23)
This manuscript describes the Ni-catalyzed coupling of azoles with aromatic nitriles. The use of BPh3 promotes these arylations with electronically diverse azoles and benzonitriles. While the nickel catalyst is necessary for the arylations of phenyl oxazoles, arylation of benzoxazoles with some nitriles affords the arylated products even in the absence of the Ni catalyst albeit in lower yield than the catalyzed process. The Ni-catalyzed process exhibits higher rates and a broader scope than the uncatalyzed transformation.
C-H bond activation: A versatile protocol for the direct arylation and alkenylation of oxazoles
Besselievre, Francois,Lebrequier, Sabrina,Mahuteau-Betzer, Florence,Piguel, Sandrine
experimental part, p. 3511 - 3518 (2010/02/28)
The versatile palladium, complex Pd(PPh3)4 catalyses both direct arylation and alkenylation of oxazoles efficiently. The method is regioselective and stereospecific with respect to bromoalkenes and tolerates a wide range of functional groups.
Ligandless microwave-assisted Pd/Cu-catalyzed direct arylation of oxazoles
Besselievre, Francois,Mahuteau-Betzer, Florence,Grierson, David S.,Piguel, Sandrine
, p. 3278 - 3280 (2008/09/19)
(Chemical Equation Presented) An efficient microwave-assisted palladium/copper co-mediated direct arylation of oxazoles with aryl bromides under ligandless conditions has been developed. The method is functional group tolerant and provides rapid access to medicinally relevant compounds in good yields. Coupled to the van Leusen oxazole ring synthesis, this methodology is illustrated by an expedient two-step synthesis of the four 2,5-diaryloxazole alkaloids texamine, texaline, balsoxin, and O-Me-halfordinol from commercially available starting materials.
