439107-94-5

Basic information

• Product Name: 6-BROMO-1-BENZOFURAN-2-CARBOXYLIC ACID
• Synonyms: 6-BROMO-1-BENZOFURAN-2-CARBOXYLIC ACID;6-BROMOBENZOFURAN-2-CARBOXYLIC ACID;2-Benzofurancarboxylic acid, 6-broMo-;6-bromo-2-Benzofurancarboxylic acid
• CAS NO: 439107-94-5
• Molecular Formula: C₉H₅BrO₃
• Molecular Weight: 241.04
• Mol File: 439107-94-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 370.9 °C at 760 mmHg
• Flash Point: 178.1 °C
• Appearance: /
• Density: 1.784 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 6-BROMO-1-BENZOFURAN-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BROMO-1-BENZOFURAN-2-CARBOXYLIC ACID(439107-94-5)
• EPA Substance Registry System: 6-BROMO-1-BENZOFURAN-2-CARBOXYLIC ACID(439107-94-5)

Safety Data

• Hazardous Substances Data: 439107-94-5(Hazardous Substances Data)

Usage

General Description

6-Bromo-1-benzofuran-2-carboxylic acid is a chemical compound with the molecular formula C9H5BrO3. It is a carboxylic acid derivative and contains a benzofuran ring with a bromine atom at the 6th position and a carboxylic acid group at the 2nd position. 6-Bromo-1-benzofuran-2-carboxylic acid is often used as a building block in organic synthesis and medicinal chemistry to create diverse molecules with potential biological activity. Its structure and properties make it useful for the development of pharmaceuticals and agrochemicals. Additionally, 6-Bromo-1-benzofuran-2-carboxylic acid can also serve as an important intermediate in the production of various chemical compounds.

Upstream product

• 22532-62-3 4-bromosalicylaldehyde 
• 96-34-4 methyl chloroacetate 

Relevant articles and documents

Synthesis and biological evaluation of novel shikonin-benzo[b]furan derivatives as tubulin polymerization inhibitors targeting the colchicine binding site

A novel series of shikonin-benzo[b]furan derivatives were designed and synthesized as tubulin polymerization inhibitors, and their biological activities were evaluated. Most compounds revealed the comparable anti-proliferation activities against the cancer cell lines to that of shikonin and simultaneously low cytotoxicity to non-cancer cells. Among them, compound 6c displayed powerful anti-cancer activity with the IC50 value of 0.18 μM against HT29 cells, which was significantly better than that of the reference drugs shikonin and CA-4. What's more, 6c could inhibit tubulin polymerization and compete with [3H] colchicine in binding to tubulin. Further biological studies depicted that 6c can induce cell apoptosis and cell mitochondria depolarize, regulate the expression of apoptosis related proteins in HT29 cells. Besides, 6c actuated the HT29 cell cycle arrest at G2/M phase, and influenced the expression of the cell-cycle related protein. Moreover, 6c displayed potent inhibition on cell migration and tube formation that contributes to the antiangiogenesis. These results prompt us to consider 6c as a potential tubulin polymerization inhibitor and is worthy for further study.

CATHEPSIN K INHIBITOR AND APPLICATION THEREOF

The invention relates to capthepsin K inhibitors and uses thereof, specifically relates to a class of compounds having the formula (I) which are used for treating or preventing cathepsin dependent diseases or conditions, specifically, wherein the cathepsin is capthepsin K. The compounds and compositions thereof can be used as bone resorption inhibitors for the treatment of associated diseases.

2-HETEROARYL CARBOXAMIDES

The invention relates to the novel 2-heteroaryl carboxamides according to formula (I), wherein R1 represents 1-aza-bicyclo [2.2.2]oct-3-yl, which is optionally replaced via the nitrogen atom by a group selected from the family C1-C4 alkyl, benzyl and oxy, A represents oxygen or sulfur, the ring B represents benzo or pyrido that are optionally replaced by the groups from the family of halogen, cyano, formyl, trifluoromethyl, trifluoromethoxy, nitro, amino, C1-C6 alkyl and C1-C6 alkoxy, E represents C=C, aryl and heteroaryl, wherein aryl and heteroaryl may be replaced by groups from the family of halogen, cyano, trifluoromethyl, trifluoromethoxy, nitro, amino, C1-C6 alkoxy and C1-C6 alkyl, and to the solvents, salts or solvents of salts of said compounds. The invention also relates to the use of said compounds in the production of drugs for the treatment and/or the prophylaxis of diseases and for improving perception, power of concentration, learning power and/or retentiveness of memory.