439114-13-3

Usage

Uses

Used in Pharmaceutical Industry:
α,ω-dipropionic acid tetraethylene glycol is used as a building block for the preparation of potent dimeric inhibitors of the PSD-95-NMDA receptor interaction. Its unique structure allows for the development of compounds that can modulate the interaction between PSD-95 and NMDA receptors, which is crucial for various neurological functions and has implications in the treatment of neurological disorders.
Used in Drug Delivery Systems:
In the field of drug delivery, α,ω-dipropionic acid tetraethylene glycol is utilized as a PEG linker to improve the solubility, stability, and bioavailability of therapeutic agents. The hydrophilic PEG spacer can be attached to drug molecules or nanoparticles, enhancing their circulation time in the body and reducing their immunogenicity. This property makes it a valuable component in the design of targeted drug delivery systems for various medical applications.
Used in Chemical Synthesis:
α,ω-dipropionic acid tetraethylene glycol can also be employed as an intermediate in the synthesis of various chemical compounds, such as polymers, surfactants, and other specialty chemicals. Its reactive carboxylic acid groups and hydrophilic PEG spacer make it a useful building block for creating novel materials with specific properties tailored for different industries.

Upstream product

• 41263-79-0 4,7,10,13,16-pentaoxanonadecane-1,14-dinitrile 
• 112-60-7 Tetraethylene glycol 
• 439114-12-2 tert-Butyl 3-[2-(2-{2-[2-(2-tert-butoxycarbonylethoxy)ethoxy]ethoxy}ethoxy)-ethoxy]propionate 
• 76-05-1 trifluoroacetic acid 

Downstream Products

• 909008-17-9 C₃₀H₄₇NO₁₂ 

Relevant academic research and scientific papers

ANTI-ANGIOGENIC COMPOUNDS

The present invention provides AA targeting compounds which comprise AA targeting agent-linker conjugates which are linked to a combining site of an antibody. Various uses of the compounds are provided, including methods to treat disorders connected to abnormal angiogenesis.

Anti-angiogenic compounds

The present invention provides AA targeting compounds which comprise AA targeting agent-linker conjugates which are linked to a combining site of an antibody. Various uses of the compounds are provided, including methods to treat disorders connected to abnormal angiogenesis.

Diphenylazetidinone derivatives, process for their preparation, medicaments comprising these compounds and their use

Compounds of the formula I, in which R1, R2, R3, R4, R5, and R6 have the meanings given in the description, and their physiologically acceptable salts. The compounds are suitable for use, for example, as hypolipidemics.

Intramolecular End-to-End Reactions of Photoactive Terminal Groups Linked by Poly(oxyethylene) Chains

The triplet-sensitized photochemical reaction using a series of poly(oxyethylene) chains with a pair of photoactive terminal groups, dibenzazepine (DBA) chromophores (DBA-COCH2CH2(OCH2CH2)nOCH2CH2CO-DBA, n=0-10) was examined.The photoirradiation of bichromophoric compounds caused either intra- or intermolecular reactions.These reactions were kinetically analyzed by two different methods: the measurement of deactivation processes of the reaction intermediates (excited triplet state of DBA) by nanosecond laser photolysis and the quantitative analysis of the reaction products by GPC.The intramolecular deactivation rate constant, kintra, showed a remarkable chain-length dependence; the maximum kintra value appeared at n=5 and it was found to be 5.9X104 s-1.On the other hand, the intramolecular cyclization rate also depends on the chain length; the maximum quantum yield, φintrad, was given at n=7 (φintrad=0.51).The chain length for the maximum cyclization yield shifted slightly to the longer region than that for the maximum kintra value due to the restriction of the terminal structure (anti-configuration).The results obtained for this reaction system are compared with those obtained for the previously reported polymethylene system and the effect of chain flexibility on the intramolecular ring-closure reaction is discussed.