439125-83-4Relevant academic research and scientific papers
Discovery of the first series of inhibitors of human papillomavirus type 11: Inhibition of the assembly of the E1-E2-Origin DNA complex
Yoakim, Christiane,Ogilvie, William W.,Goudreau, Nathalie,Naud, Julie,Hache, Bruno,O'Meara, Jeff A.,Cordingley, Michael G.,Archambault, Jacques,White, Peter W.
, p. 2539 - 2541 (2003)
We have discovered a series of inhibitors of the assembly of the HPV11 E1-E2-origin DNA complex, which incorporate an indandione fused to a substituted tetrahydrofuran.
Optimization and determination of the absolute configuration of a series of potent inhibitors of human papillomavirus type-11 E1-E2 protein-protein interaction: A combined medicinal chemistry, NMR and computational chemistry approach
Goudreau, Nathalie,Cameron, Dale R.,Deziel, Robert,Hache, Bruno,Jakalian, Araz,Malenfant, Eric,Naud, Julie,Ogilvie, William W.,O'Meara, Jeff,White, Peter W.,Yoakim, Christiane
, p. 2690 - 2700 (2008/02/08)
We have previously reported the discovery and initial SAR optimization of the first series of inhibitors of the human papillomavirus type-11 (HPV11) E1-E2 protein-protein interaction. These inhibitors featured an indandione system spiro-fused onto an all
Inhibitors of papilloma virus
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, (2008/06/13)
A compound of formula (I) or its enantiomers or diastereoisomers thereof: wherein: A,; X, W, R1, Y; R3; and R4 are as defined herein. The compounds of the invention may be used as inhibitors of the papilloma virus E1-E2-DN
Structure Elucidation of the First Inhibitors of Human Papillomavirus Type 11 E1-E2 Protein-Protein Interaction
Yoakim, Christiane,Goudreau, Nathalie,McGibbon, Graham A.,O'Meara, Jeff,White, Peter W.,Ogilvie, William W.
, p. 3427 - 3444 (2007/10/03)
A novel series of inhibitors of the HPV11 E1-E2 protein-protein interaction was identified. These inhibitors, which were discovered as a result of high-throughput screening, feature an indandione system spirofused onto an appropriately substituted tetrahy
