439142-70-8

Upstream product

• 501-53-1 benzyl chloroformate 
• 132491-89-5 tris(cyanoethoxymethyl)aminomethane 

Downstream Products

• 566168-35-2 {3-[2-benzyloxycarbonylamino-3-(3-tert-butoxycarbonylamino-propoxy)-2-(3-tert-butoxycarbonylaminopropoxymethyl)propoxy]propyl}carbamic acid tert-butyl ester 
• 510753-81-8 {2-[3-(4-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-butyrylamino)-propoxy]-1,1-bis-[3-(4-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-butyrylamino)-propoxymethyl]-ethyl}-carbamic acid benzyl ester 
• 510753-82-9 N-(3-{2-amino-3-[3-(4-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-butyrylamino)-propoxy]-2-[3-(4-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-butyrylamino)-propoxymethyl]-propoxy}-propyl)-4-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-butyramide 
• 510753-80-7 [2-(3-amino-propoxy)-1,1-bis-(3-amino-propoxymethyl)-ethyl]-carbamic acid benzyl ester 

Relevant academic research and scientific papers

A novel 1 → 3 C-branched isocyanate monomer for resin amplification - A pseudo PS-PEG high-loading resin

High loading resins (up to 120 nmoles/bead) were preprared by solid-phase dendrimerisation using a novel 1→3 C-branched isocyanate monomer.

Biomimetic ferrichrome: Structural motifs for switching between narrow- and broad-spectrum activities in P. putida and E. coli

A series of novel ferrichrome (FC) analogs was designed based on the X-ray structure of FC in the FhuA transporter of Escherichia coli. Two strategies were employed: the first strategy optimized the overall size and relative orientation of H-bonding inter

Enabling ScFvs as multi-drug carriers: A dendritic approach

To enable scFvs as multi-drug carriers, we designed and synthesized dendritic linker molecules bearing up to nine chlorambucil residues at the branch ends. A maleimide group was used at the focal point of the dendron for easy linkage to the scFv. Original

Solid-phase construction: High efficiency dendrimer synthesis using AB3 isocyanate-type monomers

Solid-phase synthesis is an ideal tool for reactions that require high concentrations and excess reagents and forcing chemical conditions. One such chemistry is that required for dendrimer construction. In this paper the synthesis of a series of symmetric

Syntheses of dendritic linkers containing chlorambucil residues for the preparation of antibody-multidrug immunoconjugates

A novel dendritic molecule with nine chlorambucil (CBL) residues on the surface and a maleimide moiety at the core terminus was synthesized using a convergent synthetic methodology. This molecule is ready for attachment to single-chain Fv antibodies (scFv