439290-93-4Relevant academic research and scientific papers
Pyrazolo[3,4-c]pyridines as gsk-3 inhibitors
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, (2008/06/13)
A compound of formula (I) or a derivative thereof, wherein R1 is unsubstituted or substituted alkyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted cycloalkenyl, unsubstituted or subs
5-Aryl-pyrazolo[3,4-b]pyridazines: Potent inhibitors of glycogen synthase kinase-3 (GSK-3)
Witherington, Jason,Bordas, Vincent,Haigh, David,Hickey, Deirdre M. B.,Ife, Robert J.,Rawlings, Anthony D.,Slingsby, Brian P.,Smith, David G.,Ward, Robert W.
, p. 1581 - 1584 (2007/10/03)
Introduction of a nitrogen atom into the 6-position of a series of pyrazolo[3,4-b]pyridines led to a dramatic improvement in the potency of GSK-3 inhibition. Rationalisation of the binding mode suggested participation of a putative structural water molecule, which was subsequently confirmed by X-ray crystallography.
