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Propan-2-yl({[4-(propan-2-yl)phenyl]methyl})amine is a complex organic compound with the molecular formula C14H23N. It is a derivative of benzene, with a propyl group (propan-2-yl) attached to the para position (4-position) of the benzene ring. Additionally, the molecule features a secondary amine group, which is connected to the benzene ring through a methylene bridge (-CH2-). propan-2-yl({[4-(propan-2-yl)phenyl]methyl})amine is characterized by its unique structure, which includes a combination of aliphatic and aromatic moieties, making it a potential candidate for various chemical and pharmaceutical applications. Its specific properties, such as solubility, reactivity, and potential uses, would depend on its ability to form hydrogen bonds and its steric hindrance, which are influenced by the presence of the propyl groups.

4395-74-8

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4395-74-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 4395-74-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,3,9 and 5 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 4395-74:
(6*4)+(5*3)+(4*9)+(3*5)+(2*7)+(1*4)=108
108 % 10 = 8
So 4395-74-8 is a valid CAS Registry Number.

4395-74-8Relevant academic research and scientific papers

SMALL-MOLECULE INHIBITORS FOR THE Β-CATENIN/B-CELL LYMPHOMA 9 PROTEIN?PROTEIN INTERACTION

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Page/Page column 51; 144, (2021/04/01)

Disclosed are inhibitors for the β-catenin/B-cell lymphoma 9 interaction. The inhibitors are selective for β-catenin/B-cell lymphoma 9 over β-catenin/ E-cadherin PPI interaction. Methods of using the disclosed compounds to treat cancer are also disclosed.

Discovery of 2-(3-(3-Carbamoylpiperidin-1-yl)phenoxy)acetic Acid Derivatives as Novel Small-Molecule Inhibitors of the β-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction

Wang, Zhen,Zhang, Min,Luo, Wen,Zhang, Yongqiang,Ji, Haitao

, p. 5886 - 5904 (2021/06/01)

The β-catenin/B-cell lymphoma 9 (BCL9) protein-protein interaction (PPI) is a potential target for the suppression of hyperactive Wnt/β-catenin signaling that is vigorously involved in cancer initiation and development. Herein, we describe the medicinal chemistry optimization of a screening hit to yield novel small-molecule inhibitors of the β-catenin/BCL9 interaction. The best compound 30 can disrupt the β-catenin/BCL9 interaction with a Ki of 3.6 μM in AlphaScreen competitive inhibition assays. Cell-based experiments revealed that 30 selectively disrupted the β-catenin/BCL9 PPI, while leaving the β-catenin/E-cadherin PPI unaffected, dose-dependently suppressed Wnt signaling transactivation, downregulated oncogenic Wnt target gene expression, and on-target selectively inhibited the growth of cancer cells harboring aberrant Wnt signaling. This compound with a new chemotype can serve as a lead compound for further optimization of inhibitors for β-catenin/BCL9 PPI.

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