4395-98-6

Basic information

• Product Name: 4-Cyanopiperidine
• Synonyms: 4-CYANOPIPERIDINE;CHEMBRDG-BB 4009819;PIPERIDINE-4-CARBONITRILE;4-CYANOPIPERIDINE >98%;4-CYANO PIPERIDINE PIPERIDINE-4-CARBONITRILE;5-AMINOPHTHALONITRILE;piperidine-4-carbonitrile(SALTDATA: HCl);4-cyanopiperdine
• CAS NO: 4395-98-6
• Molecular Formula: C₆H₁₀N₂
• Molecular Weight: 110.16
• EINECS: 1308068-626-2
• Product Categories: Amines and Anilines;Boron, Nitrile, Thio,& TM-Cpds;Piperidine;Aromatics
• Mol File: 4395-98-6.mol
• Article Data: 22

Chemical Properties

• Melting Point: 0°C
• Boiling Point: 0°C
• Flash Point: 0°C
• Appearance: Colorless to pale yellow/Liquid
• Density: 0.987 g/mL at 25 °C
• Vapor Pressure: 0.082mmHg at 25°C
• Refractive Index: 1.4755
• Storage Temp.: 2-8°C
• Solubility: Soluble in chloroform.
• PKA: 9.26±0.10(Predicted)
• CAS DataBase Reference: 4-Cyanopiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Cyanopiperidine(4395-98-6)
• EPA Substance Registry System: 4-Cyanopiperidine(4395-98-6)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 20/21/22-36/37/38-41-22
• Safety Statements: 26-36/37/39-36-39
• RIDADR: 3276
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 4395-98-6(Hazardous Substances Data)

Usage

Chemical Properties

Yellowish-Orangish Oil

Uses

4-Cyanopiperidine is used as an intermediate for the preparation of pharmaceutical substances like antidepressants and anti-inflammatory. It is used as a precursor for the synthesis of piperidine derivatives.

InChI:InChI=1/C6H10N2/c7-5-6-1-3-8-4-2-6/h6,8H,1-4H2

Upstream product

• 39546-32-2 4-carboxamidopiperidine 
• 77940-79-5 4-cyano-1-trifluoroacetylpiperidine 
• 498-94-2 isonipecotic acid 
• 91419-48-6 4-carbamoyl-piperidine-1-carboxylic acid tert-butyl ester 
• 91419-52-2 1-tert-butoxycarbonyl-4-cyanopiperidine 

Downstream Products

• 112401-09-9 piperidine-4-carbothioamide 
• 138522-66-4 1-<2-bis(4-fluorophenyl)methoxyethyl>-4-cyanopiperidine 
• 91419-52-2 1-tert-butoxycarbonyl-4-cyanopiperidine 
• 198554-64-2 1-(benzoyl)piperidine-4-carbonitrile 
• 516511-95-8 1-[2-(4-benzyl-phenoxy)-ethyl]-piperidine-4-carbonitrile 
• 713147-47-8 1-cyclopropyl piperidine-4-carbonitrile 
• 713147-51-4 1-isopropylpiperidine-4-carbonitrile 
• 1117918-50-9 1-(2-chloro-6-(4-fluorophenyl)-pyrimidin-4-yl)-piperidine-4-carbonitrile 
• 173086-95-8 1,4-dibenzylpiperidine-4-carbonitrile 
• 62718-31-4 1-benzylpiperidine-4-carbonitrile 
• 1082951-20-9 1-benzyl-piperidine-4-carbonitrile hydrochloride 
• 1146523-92-3 1-{3-[3-(3-fluorophenyl)-1H-pyrazol-5-yl]pyridin-2-yl}piperidine-4-carbonitrile 
• 1148046-75-6 4-cyano-N-(2,5-dimethylphenyl)-1-piperidinecarboxamide 
• 1190979-80-6 1-(3-chloro-4-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yloxy)benzyl)piperidine-4-carbonitrile 

Relevant articles and documents

Corresponding amine nitrile and method of manufacturing thereof

The invention relates to a manufacturing method of nitrile. Compared with the prior art, the manufacturing method has the characteristics of significantly reduced using amount of an ammonia source, low environmental pressure, low energy consumption, low production cost, high purity and yield of a nitrile product and the like, and nitrile with a more complex structure can be obtained. The invention also relates to a method for manufacturing corresponding amine from nitrile.

SULFONAMIDE DERIVATIVES AND METHODS OF USE THEREOF FOR IMPROVING THE PHARMACOKINETICS OF A DRUG

The present invention relates to Sulfonamide Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, W, X, R1, R2, R3, R4 and R5 are as defined herein. The present invention also relates to compositions comprising at least one Sulfonamide Derivative, and methods of using the Sulfonamide Derivatives for improving the pharmacokinetics of a drug.

SULFONAMIDE DERIVATIVES AND METHODS OF USE THEREOF FOR IMPROVING THE PHARMACOKINETICS OF A DRUG

The present invention relates to Sulfonamide Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, W, X, R1, R2, R3, R4 and R5 are as defined herein. The present invention also relates to compositions comprising at least one Sulfonamide Derivative, and methods of using the Sulfonamide Derivatives for improving the pharmacokinetics of a drug.