4395-98-6

Usage

Uses

Used in Pharmaceutical Industry:
4-Cyanopiperidine is used as an intermediate for the preparation of pharmaceutical substances such as antidepressants and anti-inflammatory drugs. Its presence in the synthesis process allows for the development of various medications that can help treat a range of conditions, including mood disorders and inflammation.
As a Precursor for Synthesis:
4-Cyanopiperidine serves as a precursor for the synthesis of piperidine derivatives. These derivatives are valuable in the creation of a variety of chemical compounds, including those with potential therapeutic applications. By using 4-Cyanopiperidine as a starting material, chemists can explore new pathways for the development of innovative pharmaceuticals and other useful compounds.

InChI:InChI=1/C6H10N2/c7-5-6-1-3-8-4-2-6/h6,8H,1-4H2

Upstream product

• 39546-32-2 4-carboxamidopiperidine 
• 77940-79-5 4-cyano-1-trifluoroacetylpiperidine 
• 498-94-2 isonipecotic acid 
• 91419-48-6 4-carbamoyl-piperidine-1-carboxylic acid tert-butyl ester 
• 91419-52-2 1-tert-butoxycarbonyl-4-cyanopiperidine 

Downstream Products

• 112401-09-9 piperidine-4-carbothioamide 
• 138522-66-4 1-<2-bis(4-fluorophenyl)methoxyethyl>-4-cyanopiperidine 
• 91419-52-2 1-tert-butoxycarbonyl-4-cyanopiperidine 
• 516511-95-8 1-[2-(4-benzyl-phenoxy)-ethyl]-piperidine-4-carbonitrile 
• 713147-47-8 1-cyclopropyl piperidine-4-carbonitrile 
• 713147-51-4 1-isopropylpiperidine-4-carbonitrile 
• 173086-95-8 1,4-dibenzylpiperidine-4-carbonitrile 
• 1190979-80-6 1-(3-chloro-4-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yloxy)benzyl)piperidine-4-carbonitrile 
• 1181664-35-6 1-(4-bromobenzyl)piperidine-4-carbonitrile 
• 1408865-76-8 C₁₂H₂₀N₂O 
• 1177196-47-2 1-((4-methoxyphenyl)sulfonyl)piperidine-4-carbonitrile 
• 951625-94-8 C₆H₁₃N₃ 
• 1378368-34-3 1-(4-(3-(tert-butyl)-4-isopropoxyphenyl)pyrimidin-2-yl)piperidine-4-carbonitrile 
• 1391635-95-2 C₁₇H₂₁ClN₂O₂ 

Relevant academic research and scientific papers

Corresponding amine nitrile and method of manufacturing thereof

The invention relates to a manufacturing method of nitrile. Compared with the prior art, the manufacturing method has the characteristics of significantly reduced using amount of an ammonia source, low environmental pressure, low energy consumption, low production cost, high purity and yield of a nitrile product and the like, and nitrile with a more complex structure can be obtained. The invention also relates to a method for manufacturing corresponding amine from nitrile.

COSMETIC COMPOSITIONS WITH TRICYCLODECANE AMIDES

The invention is directed to a cosmetic composition and the precursor thereof. The composition has solid agent and liquid agent, both of which are cosmetic benefit ingredients. The solubility of solid agents in liquid agents in the inventive compositions is enhanced in the presence of a tricyclodecane amide.

SULFONAMIDE DERIVATIVES AND METHODS OF USE THEREOF FOR IMPROVING THE PHARMACOKINETICS OF A DRUG

The present invention relates to Sulfonamide Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, W, X, R1, R2, R3, R4 and R5 are as defined herein. The present invention also relates to compositions comprising at least one Sulfonamide Derivative, and methods of using the Sulfonamide Derivatives for improving the pharmacokinetics of a drug.

SULFONAMIDE DERIVATIVES AND METHODS OF USE THEREOF FOR IMPROVING THE PHARMACOKINETICS OF A DRUG

The present invention relates to Sulfonamide Derivatives of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A, W, X, R1, R2, R3, R4 and R5 are as defined herein. The present invention also relates to compositions comprising at least one Sulfonamide Derivative, and methods of using the Sulfonamide Derivatives for improving the pharmacokinetics of a drug.

SULFONAMIDE DERIVATIVES AND METHODS OF USE THEREOF FOR IMPROVING THE PHARMACOKINETICS OF A DRUG

The present invention relates to Sulfonamide Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, W, X, R1, R2, R3, R4 and R5 are as defined herein. The present invention also relates to compositions comprising at least one Sulfonamide Derivative, and methods of using the Sulfonamide Derivatives for improving the pharmacokinetics of a drug.

SULFONAMIDE DERIVATIVES AND METHODS OF USE THEREOF FOR IMPROVING THE PHARMACOKINETICS OF A DRUG

The present invention relates to Sulfonamide Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, W, X, R1, R2, R3, R4 and R5 are as defined herein. The present invention also relates to compositions comprising at least one Sulfonamide Derivative, and methods of using the Sulfonamide Derivatives for improving the pharmacokinetics of a drug.

PHOTOPROTECTIVE COMPOSITIONS WITH TRICYCLODECANE AMIDES

A personal care photoprotective composition is provided having a UV-A and UV-B sunscreen in conjunction with a tricyclodecane amide. The tricyclodecane amide functions to boost UV-A, UV-B and SPF performance when the personal care composition is applied to skin or hair of the human body.

PROLONGED DELIVERY OF CERTAIN FRAGRANCE COMPONENTS FROM PERSONAL CARE COMPOSITIONS

A personal care composition is provided having a highly volatile fragrance which incorporates alpha pinene, beta pinene, hexyl acetate, limonene, (+) –citronellal, dihydromyrcenol, alpha citronellol, beta citronellol, genaniol, lilial or combinations thereof in conjunction with tricyclodecane amide. The tricyclodecane amide functions to prevent fast volatilization of the highly volatile fragrance components when the personal care composition is applied to skin or hair of the human body.

THIAZOLE SULFONAMIDE AND OXAZOLE SULFONAMIDE KINASE INHIBITORS

The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents

OCTAHYDROPYRROLO [3, 4-C] PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS

Chemokine receptor antagonists, in particular, 3,7-diazabicyclo [3.3.0] octane compounds according to formula (I) wherein R1-R3 and Ar are as defined herein are antagonists of chemokine CCR5 receptors which are useful for treating or preventing an human immunodeficiency virus (HIV) infection, or treating AIDS or ARC. The invention further provides methods for treating diseases that are alleviated with CCR5 antagonists. The invention includes pharmaceutical compositions and methods of using the compounds for the treatment of these diseases. The invention further includes processes for the preparation of compounds according to formula (I).