439579-57-4Relevant academic research and scientific papers
Samarium(II) iodide-mediated intramolecular conjugate additions of alpha,beta-unsaturated lactones.
Molander, Gary A,St Jean Jr., David J
, p. 3861 - 3865 (2002)
Samarium(II) iodide, in the presence of catalytic amounts of nickel(II) iodide, has been used to promote intramolecular conjugate additions of alkyl halides onto alpha,beta-unsaturated lactones. This process has been shown to be applicable to a number of alpha,beta-unsaturated lactones, including tetrasubstituted olefins, and has been demonstrated to be quite general for the formation of saturated bicyclic and tricyclic lactones. The method presented herein provides a mild, efficient process to form structurally complex lactones from simple precursors.
