439612-47-2Relevant academic research and scientific papers
Novel heterocyclic thyromimetics
Haning, Helmut,Woltering, Michael,Mueller, Ulrich,Schmidt, Gunter,Schmeck, Carsten,Voehringer, Verena,Kretschmer, Axel,Pernerstorfer, Josef
, p. 1835 - 1840 (2007/10/03)
Novel heterocycle-fused thyromimetics are presented carrying indoles or indazoles instead of the phenolic group in T3. Potent agonists were identified in both series. SAR trends are examined and found to be mostly consistent with previously published thyromimetics. Moderate THRβ selectivity (approx. 10-fold) was observed in the indole series using isoform-selective transient THR transfection assays
Indole derivatives
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, (2008/06/13)
The invention relates to new indole derivatives, processes for their preparation, and their use in medicaments.
