439692-55-4

Usage

Uses

Used in Pharmaceutical Industry:
6-TERT-BUTYL-4-CHLOROTHIENO[2,3-D]PYRIMIDINE is used as a building block for the synthesis of various pharmaceutical compounds. Its unique structure and reactivity make it a valuable component in the development of novel drug candidates.
Used as a Ligand in Metal-Catalyzed Reactions:
6-TERT-BUTYL-4-CHLOROTHIENO[2,3-D]PYRIMIDINE serves as a ligand in metal-catalyzed reactions, playing a crucial role in enhancing the efficiency and selectivity of these processes.
Used as a Research Tool in Chemical Biology:
6-TERT-BUTYL-4-CHLOROTHIENO[2,3-D]PYRIMIDINE is utilized as a research tool in chemical biology, aiding scientists in understanding the interactions between small molecules and biological targets, as well as in the discovery of new therapeutic agents.

Upstream product

• 439692-54-3 6-tert-butyl-4-oxothieno[2,3-d]pyrimidine 
• 216574-71-9 2-amino-5-tert-butylthiophene-3-carboxylic acid methyl ester 
• 175137-03-8 methyl 3-amino-5-tert-butylthiophene-2-carboxylate 

Relevant academic research and scientific papers

Thiophene [2, 3 - d] pyrimidine derivatives, their preparation and use thereof

The invention provides a thiophene [2, 3-d] pyrimidine derivative containing isoxazole heterocycle shown by formula (I) or a pharmaceutically accepted salt thereof, wherein R1 and R2 are respectively selected from hydrogen, C1-6 alkyl, C1-6 alkoxy, haloge

THIOPHENE [2, 3-D]PYRIMIDINE DERIVATIVE, AND PREPARATION METHOD AND USE THEREOF

This invention provides thieno[2,3-d]pyrimidine derivatives containing isoxazole heterocycle represented by formula (I), or pharmaceutically acceptable salts thereof Wherein: R1 and R2 may be the same or different and is independentl

Discovery of novel thieno[2,3-d]pyrimidin-4-yl hydrazone-based inhibitors of Cyclin D1-CDK4: Synthesis, biological evaluation and structure-activity relationships. Part 2

The design, synthesis and evaluation of novel thieno[2,3-d]pyrimidin-4-yl hydrazone analogues as cyclin-dependent kinase 4 (CDK4) inhibitor are described. Focusing on the optimization of the heteroaryl moiety at the hydrazone with substituted phenyl group

Discovery of novel thieno[2,3-d]pyrimidin-4-yl hydrazone-based inhibitors of Cyclin D1-CDK4: Synthesis, biological evaluation, and structure-activity relationships

The synthesis and evaluation of new analogues of thieno[2,3-d]pyrimidin-4-yl hydrazones are described. 2-Pyrdinecarboxaldehyde [6-(tert-butyl)thieno[2,3-d]pyrimidine-4-yl]hydrazone derivatives have been identified as cyclin-dependent kinase 4 (CDK4) inhibitors. The potency, selectivity profile, and structure-activity relationship of this series of compounds are discussed.