439807-30-4Relevant academic research and scientific papers
Asymmetric transfer hydrogenation of α-aminoalkyl α′-chloromethyl ketones with chiral Rh complexes
Hamada, Takayuki,Torii, Takayoshi,Onishi, Tomoyuki,Izawa, Kunisuke,Ikariya, Takao
, p. 7391 - 7394 (2004)
Asymmetric transfer hydrogenation of N-substituted (3S)-3-amino-1-chloro-4- phenyl-2-butanones in the presence of Cp*RhCl[(R,R)-Tsdpen] (S/C = 1000) with a mixture of formic acid/triethylamine gave N-substituted (2R,3S)-3-amino-1-chloro-2-hydroxy-4-phenylbutanes with up to 93% de in a quantitative yield, and reduction with the enantiomeric catalyst Cp*RhCl[(S,S)-Tsdpen] gave (2S.3S)-diastereomeric alcohol with up to 96% de.
PROCESS FOR PRODUCING OPTICALLY ACTIVE HALOHYDRIN COMPOUND
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, (2008/06/13)
A process of preparing an optically active halohydrin compound characterized by comprising asymmetric hydrogen transfer reduction of an α-haloketone compound in the presence of a group 9 transition metal compound having a substituted or unsubstituted cyclopentadienyl group and an optically active diamine compound. The asymmetric hydrogen transfer reduction is preferably conducted in the presence of a base.
Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors
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Page column 32, (2010/01/30)
Succinoylamino hydroxyethylamino sulfonyl urea derivatives of the formula: wherein the substituents are as defined in the specification, are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
