439857-80-4Relevant academic research and scientific papers
Synthetic replacement of the methylamino group of neocarzinostatin chromophore with hydroxyl prohibits thiol activation in organic solvents and diminishes the rate and efficiency of thiol-promoted DNA cleavage in water
Myers, Andrew G.,Liang, Jun,Hammond, Marlys
, p. 5129 - 5133 (2007/10/03)
A synthesis of the neocarzinostatin chromophore analog 2, in which the 2'-N-methylamino group of the natural product has been replaced by a hydroxyl group, is described. Thiol addition experiments in organic solvents and DNA- cleavage studies in aqueous s
