439867-73-9

Upstream product

• 439867-72-8 (1E,6E)-(R)-8-(tert-Butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-1-((S)-4-methyl-3,6-dihydro-2H-pyran-2-yl)-octa-1,6-dien-3-one 
• 439867-59-1 (S)-3-[(E)-(R)-6-(tert-Butyl-dimethyl-silanyloxy)-2-(4-methoxy-benzyloxy)-hex-4-enoyl]-4-isopropyl-oxazolidin-2-one 
• 439867-60-4 [(E)-(R)-7-(tert-Butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2-oxo-hept-5-enyl]-phosphonic acid dimethyl ester 
• 439867-70-6 (E)-(R)-6-(tert-Butyl-dimethyl-silanyloxy)-2-(4-methoxy-benzyloxy)-hex-4-enoic acid methoxy-methyl-amide 
• 439867-69-3 (E)-(R)-6-(tert-Butyl-dimethyl-silanyloxy)-2-(4-methoxy-benzyloxy)-hex-4-enoic acid 
• 439867-68-2 (R)-4-Isopropyl-3-((S)-4-methyl-3,6-dihydro-2H-pyran-2-carbonyl)-oxazolidin-2-one 
• 289472-96-4 (2S)-(4-methyl-3,6-dihydro-2H-pyran-2-yl)-methanol 
• 218898-32-9 (2S)-4-methyl-3,6-dihydro-2H-pyran-2-carbaldehyde 
• 200628-56-4 (E)-tert-butyl((4-iodobut-2-en-1-yl)oxy)dimethylsilane 
• 69739-34-0 t-butyldimethylsiyl triflate 
• 439867-61-5 (1E,6E)-(3S,4R)-8-(tert-Butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-1-((S)-4-methyl-3,6-dihydro-2H-pyran-2-yl)-octa-1,6-dien-3-ol 

Downstream Products

• 439867-63-7 C₅₈H₉₀O₉Si₂ 
• 439867-74-0 1-{3-[3-(tert-butyl-dimethyl-silanyloxy)-2-(4-methoxy-benzyloxy)-5-(4-methyl-3,6-dihydro-2H-pyran-2-yl)-pent-4-enyl]-oxiranyl}-3-(3-{6-[4-(4-methoxy-benzyloxy)-but-2-enyl]-3,6-dihydro-2H-pyran-2-yl}-2-methyl-propyl)-but-3-en-1-ol 
• 115268-43-4 laulimalide 
• 439867-62-6 (2E,7E)-(5R,6S)-6-(tert-Butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-8-((S)-4-methyl-3,6-dihydro-2H-pyran-2-yl)-octa-2,7-dien-1-ol 

Relevant academic research and scientific papers

Asymmetric total synthesis of (-)-laulimalide: Exploiting the asymmetric glycolate alkylation reaction

A concise total synthesis of the potent antitumor macrolide (-)-laulimalide is described. The observation that homoallylic (or latent homoallylic) C-O bonds are present at C5, C9, C15, C19, and C23 led to the strategic decision to rely heavily on the asym