440112-17-4Relevant academic research and scientific papers
SULFONAMIDE COMPOUNDS USEFUL AS CYP17 INHIBITORS
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Page/Page column 78, (2012/02/13)
Disclosed are sulfonamide compounds of Formula (I): or stereoisomers, N-oxides, prodrugs, or pharmaceutically acceptable salts thereof, wherein ring A, R1, R2, R3, R4 and R5 are defined herein. Also disclosed are methods of using such compounds in the treatment of conditions related to CYP17 enzyme, such as cancer, and pharmaceutical compositions comprising such compounds.
Directed deprotonation-transmetallation of 4-bromopyridine: Flexible routes to substituted pyridines
Karig, Gunter,Thasana, Nopporn,Gallagher, Timothy
, p. 808 - 810 (2007/10/03)
Halide-directed deprotonation and Li-Zn exchange of 4-bromopyridine 4 provides organozinc 6, which undergoes Pd-mediated coupling to give the 3-aryl-4-bromopyridines 7. Further substitution is achieved to provide the 3,4-disubstituted pyridines 8 and 9, a
