440117-40-8Relevant academic research and scientific papers
An efficient synthesis of quinoxaline derivatives mediated by stannous chloride
Shi, Da-Qing,Dou, Guo-Lan,Ni, Sai-Nan,Shi, Jing-Wen,Li, Xiao-Yue
, p. 1797 - 1801 (2008)
(Chemical Equation Presented) Various biologically important quinoxaline derivatives were efficiently synthesized in excellent yields by the reaction of 1,2-diketones and 2-nitroaniline, benzofuroxan or 1,2-dinitrobenzene promoted by SnCl2·2H2O. The role of stannous chloride is acting as both reductive agent and catalyst in this synthesis. This new method has the advantages of accessible starting materials, convenient manipulation, short reaction time and high yields.
In water organic synthesis: Introducing itaconic acid as a recyclable acidic promoter for efficient and scalable synthesis of quinoxaline derivatives at room temperature
Tamuli, Kashyap J.,Nath, Shyamalendu,Bordoloi, Manobjyoti
supporting information, p. 983 - 1002 (2021/02/27)
Substituted quinoxaline derivatives are traditionally synthesized by co-condensation of various starting materials. Herein, we describe a novel environmentally benign in water synthetic route for the synthesis of structurally and electronically diverse ninety quinoxalines with readily available substituted o-phenylenediamine and 1,2-diketones using cheap and biodegradable itaconic acid as a mild acid promotor in 1 hours. The reaction is performed at room temperature, which proceeds through cyclo-condensation reaction followed by obtaining the aforesaid nitrogen-containing heterocyclic adducts without performing the column chromatography up to 96% total yields. The simplicity, high efficiency, and reusable of the catalyst merits this reaction condition as “green synthesis” which enables it to be useful in synthetic transformations upto gram scale level.
