440125-15-5Relevant academic research and scientific papers
Norstatines from Aldehydes by sequential organocatalytic α-amination and passerini reaction
Umbreen, Sumaira,Brockhaus, Manfred,Ehrenberg, Helmut,Schmidt, Boris
, p. 4585 - 4595 (2007/10/03)
The combination of the enantioselective, organocatalytic α-amination of aldehydes by diazodicarboxylates and the Passerini reaction provides rapid access to norstatine-based peptidomimetics. These intermediates were elaborated further by deprotection and cleavage of the N-N bond to provide useful building blocks for aspartic protease inhibitors. Coupling of the compounds 76-86 with the mono-isophthalamide 91 provided moderate inhibitors of human β-secretase (BACE) 92-102. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.
AMIDINO COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS
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Page/Page column 46-47, (2010/02/09)
The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceu
PEPTIDIC COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS
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Page 69, (2010/11/30)
The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.
