440127-35-5Relevant academic research and scientific papers
NOVEL KETO-OXADIAZOLE DERIVATIVES AS CATHEPSIN INHIBITORS
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Page/Page column 41, (2008/06/13)
Novel difluorinated amide derivatives of Formula (II) as inhibitors of cathepsin S, K, B, and L, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
HALOALKYL CONTAINING COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS
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Page/Page column 48-49, (2010/02/11)
The application is directed to haloalkyl-substituted compounds of Formula (I), wherein R1, R1a, R2, R3, R4’ and E are as defined in the claims. The compounds are inhibitors of cysteine proteases, in p
AMIDINO COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS
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Page/Page column 21-22, (2010/02/12)
The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.
SILINANE COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS
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Page/Page column 57, (2008/06/13)
The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is also directed to pharmaceutical compositions comprising these compounds and processes for preparing them. The present invention is also directed to the use of these inhibitors in combination with a therapy that causes a deleterious immune response in patients receiving the therapy.
AMIDINO COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS
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Page/Page column 47, (2010/02/09)
The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceu
PEPTIDIC COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS
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Page 70, (2010/11/30)
The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.
