440339-63-9Relevant academic research and scientific papers
Synthesis of α-D-Galp-(1→3)-β-D-Galf-(1→3)-D-Man, a terminal trisaccharide of leishmania type-2 glycoinositolphospholipids
Gandolfi-Donadio, Lucia,Gallo-Rodriguez, Carola,De Lederkremer, Rosa M.
, p. 4430 - 4435 (2002)
The synthesis of α-D-Galp-(1→3)-β-D-Galf-(1→3)-D-Man, present in the type-2 glycoinositolphospholipids and in the core of the lipophosphoglycan of Leishmania, is described. The glycosyl aldonolactone approach, followed by reduction of the lactone with diisoamylborane, was utilized for the introduction of the internal galactofuranosyl unit and the trichloroacetimidate method for the O-glycosidation reaction. A high-yield synthesis of the β-D-Galf-(1-3)-D-Man unit, also present in the lipopeptidophosphoglycan of Trypanosoma cruzi, is reported.
