440367-23-7Relevant academic research and scientific papers
Synthesis and characterization of the atropisomeric relationships of a substituted N-phenyl-bipyrazole derivative with anti-inflammatory properties
Veloso, Marcia P.,Romeiro, Nelilma C.,Silva, Gilberto M. S.,Alves, Helio De M.,Doriguetto, Antonio C.,Ellena, Javier,Miranda, Ana L. P.,Barreiro, Eliezer J.,Fraga, Carlos A. M.
, p. 463 - 470 (2012/08/28)
This work describes the atropisomeric relationships of 3-methyl-5-(3- methyl-5-phenyl-1H-pyrazol-1-yl)-1-phenyl-1H-pyrazol-4-amine (2d), which belongs to series 4-aminobipyrazole derivatives designed as anti-inflammatory agents. The 1H nuclear magnetic resonance spectra obtained in the presence of a chiral lanthanide shift salt associated to chiral high-performance liquid chromatography analysis, X-ray diffraction, and molecular modeling tools confirmed that ortho bis-functionalized bipyrazole 2d exists as a mixture of aR,aS-atropisomers. These results provide useful information to understand the pharmacological profile of this derivative and of other 4-aminobipyrazole analogs. Copyright
